Gene description for PSME3
Gene name	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Gene symbol	PSME3
Other names/aliases	HEL-S-283 Ki PA28-gamma PA28G PA28gamma REG-GAMMA
Species	Homo sapiens
Database cross references - PSME3
ExoCarta	ExoCarta_10197
Entrez Gene	10197
HGNC	9570
MIM	605129
UniProt	P61289
PSME3 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	19837982
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Thymus	23844026

Gene ontology annotations for PSME3

Molecular Function     MDM2/MDM4 family protein binding GO:0097371 IDA     endopeptidase activator activity GO:0061133 IDA     protein binding GO:0005515 IPI     p53 binding GO:0002039 IDA     identical protein binding GO:0042802 IPI Biological Process     apoptotic process GO:0006915 TAS     positive regulation of endopeptidase activity GO:0010950 IDA     innate immune response GO:0045087 TAS     positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS     regulation of cellular amino acid metabolic process GO:0006521 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS     antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS     negative regulation of apoptotic process GO:0043066 TAS     negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 TAS     gene expression GO:0010467 TAS     regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IDA     protein polyubiquitination GO:0000209 TAS     DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS     viral process GO:0016032 TAS     G1/S transition of mitotic cell cycle GO:0000082 TAS     mitotic cell cycle GO:0000278 TAS     regulation of apoptotic process GO:0042981 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS     anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     small molecule metabolic process GO:0044281 TAS     cellular nitrogen compound metabolic process GO:0034641 TAS     programmed cell death GO:0012501 TAS     regulation of proteasomal protein catabolic process GO:0061136 IDA Subcellular Localization     membrane GO:0016020 IDA     cytosol GO:0005829 TAS     cytoplasm GO:0005737 IDA     proteasome complex GO:0000502 TAS     proteasome activator complex GO:0008537 IEA     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA