Gene description for MRPL50
Gene name mitochondrial ribosomal protein L50
Gene symbol MRPL50
Other names/aliases MRP-L50
Species Homo sapiens
 Database cross references - MRPL50
ExoCarta ExoCarta_54534
Vesiclepedia VP_54534
Entrez Gene 54534
HGNC 16654
MIM 611854
UniProt Q8N5N7  
 MRPL50 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL50
Biological Process
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial large ribosomal subunit GO:0005762 IBA
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified MRPL50 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL50
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SLIRP 81892
Proximity Label-MS Homo sapiens
3 EXOSC7 23016
Affinity Capture-MS Homo sapiens
4 H1FNT  
Affinity Capture-MS Homo sapiens
5 MRPL24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MRPL48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PCF11 51585
Affinity Capture-MS Homo sapiens
8 MRPL30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MRPL17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 XRCC2  
Affinity Capture-MS Homo sapiens
11 GTPBP10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RPL26 6154
Affinity Capture-MS Homo sapiens
13 TRUB2  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MTG2  
Proximity Label-MS Homo sapiens
15 NGRN  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CHCHD1  
Proximity Label-MS Homo sapiens
17 MRPL37 51253
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MRPL27 51264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TBC1D8  
Affinity Capture-MS Homo sapiens
20 MRPL52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RPUSD4 84881
Proximity Label-MS Homo sapiens
22 THAP9  
Affinity Capture-MS Homo sapiens
23 MRPL49 740
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DNAJC15  
Proximity Label-MS Homo sapiens
25 MTRF1  
Proximity Label-MS Homo sapiens
26 GFM2 84340
Proximity Label-MS Homo sapiens
27 CCDC90B  
Proximity Label-MS Homo sapiens
28 ILF2 3608
Co-fractionation Homo sapiens
29 LRPPRC 10128
Proximity Label-MS Homo sapiens
30 KIAA1429 25962
Affinity Capture-MS Homo sapiens
31 RNPS1 10921
Affinity Capture-MS Homo sapiens
32 MCU 90550
Proximity Label-MS Homo sapiens
33 TFAM 7019
Proximity Label-MS Homo sapiens
34 PMPCA 23203
Proximity Label-MS Homo sapiens
35 C8orf82  
Proximity Label-MS Homo sapiens
36 TLN1 7094
Affinity Capture-MS Homo sapiens
37 MRPL23 6150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 YARS2  
Affinity Capture-MS Homo sapiens
39 HINT2 84681
Proximity Label-MS Homo sapiens
40 DUSP11  
Affinity Capture-MS Homo sapiens
41 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MRPL57  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 MRPS26 64949
Proximity Label-MS Homo sapiens
44 SURF1  
Proximity Label-MS Homo sapiens
45 SRSF3 6428
Affinity Capture-MS Homo sapiens
46 PTCD1 26024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 EXD2  
Proximity Label-MS Homo sapiens
48 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
49 TEX19  
Affinity Capture-MS Homo sapiens
50 MRPL39 54148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
52 ATP6V0A1 535
Co-fractionation Homo sapiens
53 NHP2 55651
Affinity Capture-MS Homo sapiens
54 PMPCB 9512
Proximity Label-MS Homo sapiens
55 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 FASTKD2  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 VWA8 23078
Proximity Label-MS Homo sapiens
58 MRPL47 57129
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 FAM120A 23196
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SLC25A3 5250
Co-fractionation Homo sapiens
61 KIF14 9928
Affinity Capture-MS Homo sapiens
62 GAR1 54433
Affinity Capture-MS Homo sapiens
63 LIN28A  
Affinity Capture-MS Homo sapiens
64 MDH2 4191
Proximity Label-MS Homo sapiens
65 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 E2F4  
Affinity Capture-MS Homo sapiens
67 MRPL13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 YBX1 4904
Affinity Capture-MS Homo sapiens
69 MRPL32 64983
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 SLC25A10 1468
Affinity Capture-MS Homo sapiens
71 C6orf203  
Proximity Label-MS Homo sapiens
72 COX15 1355
Affinity Capture-MS Homo sapiens
73 FASTKD5  
Proximity Label-MS Homo sapiens
74 MRPL45 84311
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ALDH5A1 7915
Affinity Capture-MS Homo sapiens
76 TMEM177  
Co-fractionation Homo sapiens
77 MALSU1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 MRPL20 55052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TRA2A 29896
Affinity Capture-MS Homo sapiens
80 YBX2 51087
Affinity Capture-MS Homo sapiens
81 GDF15 9518
Affinity Capture-MS Homo sapiens
82 TUFM 7284
Proximity Label-MS Homo sapiens
83 RNF213 57674
Affinity Capture-MS Homo sapiens
84 HSCB 150274
Proximity Label-MS Homo sapiens
85 RPL35 11224
Affinity Capture-MS Homo sapiens
86 SRSF7 6432
Affinity Capture-MS Homo sapiens
87 RBMS2 5939
Affinity Capture-MS Homo sapiens
88 MRPS6  
Affinity Capture-MS Homo sapiens
89 CCDC109B 55013
Proximity Label-MS Homo sapiens
90 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
91 TBRG4 9238
Proximity Label-MS Homo sapiens
92 MRPL35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 RPL27A 6157
Affinity Capture-MS Homo sapiens
94 SMC1A 8243
Affinity Capture-MS Homo sapiens
95 ATP6V1B1 525
Co-fractionation Homo sapiens
96 MTFMT  
Proximity Label-MS Homo sapiens
97 RNMTL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 MRPL11 65003
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 MTRF1L  
Proximity Label-MS Homo sapiens
100 ZC3H15 55854
Affinity Capture-MS Homo sapiens
101 TMEM70  
Proximity Label-MS Homo sapiens
102 CORO7 79585
Affinity Capture-MS Homo sapiens
103 REEP3 221035
Affinity Capture-MS Homo sapiens
104 MRPL2 51069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 MRPL16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 UBR2 23304
Affinity Capture-MS Homo sapiens
107 OXA1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 MRPL14 64928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 MRPL44  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 MRPL51 51258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 GTF3C3 9330
Affinity Capture-MS Homo sapiens
112 MRPL40 64976
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 WBSCR16  
Affinity Capture-MS Homo sapiens
114 MRPL21 219927
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 MRRF  
Proximity Label-MS Homo sapiens
116 MRPS12  
Proximity Label-MS Homo sapiens
117 MRPL10 124995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 MTIF2 4528
Proximity Label-MS Homo sapiens
119 KIF20A 10112
Affinity Capture-MS Homo sapiens
120 RC3H2  
Affinity Capture-MS Homo sapiens
121 ND5 4540
Affinity Capture-MS Homo sapiens
122 MTIF3  
Proximity Label-MS Homo sapiens
123 CYTB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 RTN4IP1  
Affinity Capture-MS Homo sapiens
125 MRPL9 65005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 Ttll12 223723
Affinity Capture-MS Mus musculus
127 RPL37 6167
Affinity Capture-MS Homo sapiens
128 PRKCZ 5590
Affinity Capture-MS Homo sapiens
129 CUL3 8452
Affinity Capture-MS Homo sapiens
130 RPUSD3  
Affinity Capture-MS Homo sapiens
131 SRSF5 6430
Affinity Capture-MS Homo sapiens
132 GADD45GIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 TST 7263
Affinity Capture-MS Homo sapiens
134 DHX30 22907
Proximity Label-MS Homo sapiens
135 MRPL15 29088
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 C12orf65  
Proximity Label-MS Homo sapiens
137 MYCN  
Affinity Capture-MS Homo sapiens
138 PRR3  
Affinity Capture-MS Homo sapiens
139 ATP5J2 9551
Affinity Capture-MS Homo sapiens
140 TACO1  
Proximity Label-MS Homo sapiens
141 MTG1  
Proximity Label-MS Homo sapiens
142 MRPL38  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 MYC  
Affinity Capture-MS Homo sapiens
144 KCNAB2 8514
Affinity Capture-MS Homo sapiens
145 MRPL46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 TSFM 10102
Proximity Label-MS Homo sapiens
147 MICALL1 85377
Affinity Capture-MS Homo sapiens
148 MRPL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 ACAD9 28976
Proximity Label-MS Homo sapiens
150 SRSF10 10772
Affinity Capture-MS Homo sapiens
151 Rpl35 66489
Affinity Capture-MS Mus musculus
152 PSME3 10197
Affinity Capture-MS Homo sapiens
153 MRPL34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 TSR1 55720
Co-fractionation Homo sapiens
155 METTL15  
Proximity Label-MS Homo sapiens
156 TPM4 7171
Affinity Capture-MS Homo sapiens
157 FLOT1 10211
Co-fractionation Homo sapiens
158 RPL19 6143
Affinity Capture-MS Homo sapiens
159 RPL13 6137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 MTERF3  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 DNAJC28  
Proximity Label-MS Homo sapiens
162 CS 1431
Proximity Label-MS Homo sapiens
163 MRPL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 MRPL33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 RC3H1 149041
Affinity Capture-MS Homo sapiens
166 AUH 549
Proximity Label-MS Homo sapiens
167 PDGFB  
Affinity Capture-MS Homo sapiens
168 MRPL22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 DNAJC19 131118
Proximity Label-MS Homo sapiens
170 MOCOS  
Affinity Capture-MS Homo sapiens
171 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 SUCLG2 8801
Co-fractionation Homo sapiens
173 LONP1 9361
Proximity Label-MS Homo sapiens
174 FOXB1  
Affinity Capture-MS Homo sapiens
175 MRPL53  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 RIF1  
Co-fractionation Homo sapiens
177 MRPL43 84545
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 DNAJA3 9093
Proximity Label-MS Homo sapiens
179 MRPS35 60488
Affinity Capture-MS Homo sapiens
180 MRPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 COX8A  
Proximity Label-MS Homo sapiens
182 MRPL54  
Affinity Capture-MS Homo sapiens
183 TRA2B 6434
Affinity Capture-MS Homo sapiens
184 C21orf33  
Proximity Label-MS Homo sapiens
185 MRPL18 29074
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 SSBP1 6742