Gene description for SRSF10
Gene name serine/arginine-rich splicing factor 10
Gene symbol SRSF10
Other names/aliases FUSIP1
FUSIP2
NSSR
PPP1R149
SFRS13
SFRS13A
SRp38
SRrp40
TASR
TASR1
TASR2
Species Homo sapiens
 Database cross references - SRSF10
ExoCarta ExoCarta_10772
Entrez Gene 10772
HGNC 16713
MIM 605221
UniProt O75494  
 SRSF10 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for SRSF10
Molecular Function
    unfolded protein binding GO:0051082 NAS
    RS domain binding GO:0050733 NAS
    poly(A) RNA binding GO:0044822 IDA
    RNA binding GO:0003723 NAS
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
Biological Process
    RNA splicing, via transesterification reactions GO:0000375 IDA
    mRNA export from nucleus GO:0006406 NAS
    mRNA splicing, via spliceosome GO:0000398 IDA
    regulation of transcription, DNA-templated GO:0006355 NAS
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IDA
    spliceosomal tri-snRNP complex assembly GO:0000244 NAS
    mRNA splice site selection GO:0006376 IDA
    cytoplasmic transport GO:0016482 IDA
Subcellular Localization
    cytoplasm GO:0005737 NAS
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IC
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified SRSF10 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SRSF10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FUS 2521
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
3 YWHAQ 10971
Affinity Capture-MS Homo sapiens
4 TRA2A 29896
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SRSF10 is involved
No pathways found





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