Gene description for Emc1
Gene name ER membrane protein complex subunit 1
Gene symbol Emc1
Other names/aliases 2700016F22Rik
Species Mus musculus
 Database cross references - Emc1
ExoCarta ExoCarta_230866
Vesiclepedia VP_230866
Entrez Gene 230866
UniProt Q8C7X2  
 Emc1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Emc1
Molecular Function
    membrane insertase activity GO:0032977 ISO
    membrane insertase activity GO:0032977 ISS
Biological Process
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 ISO
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 ISS
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISO
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 ISO
    endoplasmic reticulum membrane GO:0005789 ISS
    endoplasmic reticulum membrane GO:0005789 NAS
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    protein-containing complex GO:0032991 ISO
    EMC complex GO:0072546 IBA
    EMC complex GO:0072546 ISO
    EMC complex GO:0072546 ISS
 Experiment description of studies that identified Emc1 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Emc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MMGT1 93380
Affinity Capture-MS Homo sapiens
2 EMC7 56851
Affinity Capture-MS Homo sapiens
3 SRSF10 10772
Affinity Capture-MS Homo sapiens
4 EMC4 51234
Affinity Capture-MS Homo sapiens
5 EMC10 284361
Affinity Capture-MS Homo sapiens
6 EMC3 55831
Affinity Capture-MS Homo sapiens
7 EMC2 9694
Affinity Capture-MS Homo sapiens
8 EMC8 10328
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Emc1 is involved
No pathways found





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