Gene description for DUSP14
Gene name dual specificity phosphatase 14
Gene symbol DUSP14
Other names/aliases MKP-L
MKP6
Species Homo sapiens
 Database cross references - DUSP14
ExoCarta ExoCarta_11072
Vesiclepedia VP_11072
Entrez Gene 11072
HGNC 17007
MIM 606618
UniProt O95147  
 DUSP14 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DUSP14
Molecular Function
    RNA binding GO:0003723 HDA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 IEA
    myosin phosphatase activity GO:0017018 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
 Experiment description of studies that identified DUSP14 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DUSP14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACAD8 27034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PYCR2 29920
Affinity Capture-MS Homo sapiens
3 USP6NL 9712
Affinity Capture-MS Homo sapiens
4 LYG2  
Affinity Capture-MS Homo sapiens
5 FAM26D  
Affinity Capture-MS Homo sapiens
6 ISYNA1 51477
Two-hybrid Homo sapiens
7 ORMDL3 94103
Affinity Capture-MS Homo sapiens
8 SPERT  
Two-hybrid Homo sapiens
9 TAS2R38  
Affinity Capture-MS Homo sapiens
10 SRFBP1  
Affinity Capture-MS Homo sapiens
11 ST6GALNAC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SOX2  
Affinity Capture-MS Homo sapiens
13 PI4KA 5297
Affinity Capture-MS Homo sapiens
14 MRPS18C  
Affinity Capture-MS Homo sapiens
15 ANXA9  
Affinity Capture-MS Homo sapiens
16 VIPR2  
Affinity Capture-MS Homo sapiens
17 FBXO3  
Affinity Capture-MS Homo sapiens
18 LACC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 IL31RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SRSF10 10772
Affinity Capture-MS Homo sapiens
21 SLAMF6 114836
Affinity Capture-MS Homo sapiens
22 CPLX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SGIP1  
Affinity Capture-MS Homo sapiens
24 EPHA1 2041
Two-hybrid Homo sapiens
25 GDF5 8200
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TMTC4  
Affinity Capture-MS Homo sapiens
27 UCHL5 51377
Reconstituted Complex Homo sapiens
28 PFN2 5217
Affinity Capture-MS Homo sapiens
29 CD28  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
30 RAB39B 116442
Affinity Capture-MS Homo sapiens
31 OAZ3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 FOXP2 93986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ERBB2 2064
Two-hybrid Homo sapiens
34 KIF3A 11127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SGOL2 151246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SAMHD1 25939
Affinity Capture-MS Homo sapiens
38 HEATR1 55127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 COASY 80347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 RHOBTB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 IGF1R 3480
Two-hybrid Homo sapiens
42 ERBB3 2065
Two-hybrid Homo sapiens
43 ITGAD  
Affinity Capture-MS Homo sapiens
44 P2RY8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PEMT  
Affinity Capture-MS Homo sapiens
46 FNTB 2342
Affinity Capture-MS Homo sapiens
47 TNFSF13 8741
Affinity Capture-MS Homo sapiens
48 DTNBP1  
Affinity Capture-MS Homo sapiens
49 RAB11FIP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CCDC51 79714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 FAM136A 84908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 LRCH1 23143
Affinity Capture-MS Homo sapiens
53 SCG5  
Affinity Capture-MS Homo sapiens
54 IQUB  
Affinity Capture-MS Homo sapiens
55 HEPN1  
Affinity Capture-MS Homo sapiens
56 OR51E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 GEMIN7  
Affinity Capture-MS Homo sapiens
58 AP3B1 8546
Affinity Capture-MS Homo sapiens
59 PTK7 5754
Two-hybrid Homo sapiens
60 MCCC1 56922
Affinity Capture-MS Homo sapiens
61 ATG7 10533
Affinity Capture-MS Homo sapiens
62 B3GALNT1 8706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 ZNF543  
Affinity Capture-MS Homo sapiens
64 FBXL4 26235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 LRRC15 131578
Affinity Capture-MS Homo sapiens
66 EPDR1 54749
Affinity Capture-MS Homo sapiens
67 ROR1 4919
Two-hybrid Homo sapiens
68 KHSRP 8570
Affinity Capture-MS Homo sapiens
69 RASGRP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 HEPHL1  
Affinity Capture-MS Homo sapiens
71 SMARCD1 6602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 SPARCL1  
Affinity Capture-MS Homo sapiens
73 LPCAT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 LMTK2 22853
Two-hybrid Homo sapiens
75 ERBB4 2066
Two-hybrid Homo sapiens
76 EGFR 1956
Affinity Capture-Western Homo sapiens
77 PLD5  
Affinity Capture-MS Homo sapiens
78 NPSR1  
Affinity Capture-MS Homo sapiens
79 TFG 10342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 NXF1 10482
Affinity Capture-RNA Homo sapiens
81 SPTLC3  
Affinity Capture-MS Homo sapiens
82 UBE2D2 7322
Affinity Capture-MS Homo sapiens
83 FGFR2 2263
Two-hybrid Homo sapiens
84 EPHA2 1969
Two-hybrid Homo sapiens
85 FOS 2353
Affinity Capture-MS Homo sapiens
86 CBR4  
Affinity Capture-MS Homo sapiens
87 RAB11B 9230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 PLCD1 5333
Affinity Capture-MS Homo sapiens
89 OTULIN 90268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 SETDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 LGI1  
Affinity Capture-MS Homo sapiens
92 EDF1 8721
Affinity Capture-MS Homo sapiens
93 BMI1  
Affinity Capture-MS Homo sapiens
94 CCDC173 129881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 DYM  
Affinity Capture-MS Homo sapiens
96 MRPL38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 NPAP1  
Affinity Capture-MS Homo sapiens
98 STX17 55014
Affinity Capture-MS Homo sapiens
99 NSMAF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 PYHIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 CXorf66  
Affinity Capture-MS Homo sapiens
102 AATK  
Two-hybrid Homo sapiens
103 TRAF2 7186
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
104 GPBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 ZMYM6NB  
Affinity Capture-MS Homo sapiens
106 DRD3  
Affinity Capture-MS Homo sapiens
107 SYT16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 ISCA2 122961
Affinity Capture-MS Homo sapiens
109 APEX1 328
Affinity Capture-RNA Homo sapiens
110 GSC  
Affinity Capture-MS Homo sapiens
111 MFI2 4241
Affinity Capture-MS Homo sapiens
112 RYK 6259
Affinity Capture-MS Homo sapiens
113 CAPZA2 830
Affinity Capture-MS Homo sapiens
114 VSIG8  
Affinity Capture-MS Homo sapiens
115 NHLRC2 374354
Affinity Capture-MS Homo sapiens
116 PTDSS1 9791
Affinity Capture-MS Homo sapiens
117 C21orf33  
Affinity Capture-MS Homo sapiens
118 ANKH 56172
Affinity Capture-MS Homo sapiens
119 ROR2 4920
Two-hybrid Homo sapiens
120 ACOX1 51
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 KDELR2 11014
Affinity Capture-MS Homo sapiens
122 PMVK 10654
Affinity Capture-MS Homo sapiens
123 MAPK9 5601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 DSG4 147409
Affinity Capture-MS Homo sapiens
125 GOT1 2805
Affinity Capture-MS Homo sapiens
126 FOXN3 1112
Affinity Capture-MS Homo sapiens
127 WDR59 79726
Affinity Capture-MS Homo sapiens
128 PYCR1 5831
Affinity Capture-MS Homo sapiens
129 TPST2 8459
Affinity Capture-MS Homo sapiens
130 SRMS  
Affinity Capture-MS Homo sapiens
131 BHLHE23  
Affinity Capture-MS Homo sapiens
132 RGR  
Affinity Capture-MS Homo sapiens
133 CCR1  
Affinity Capture-MS Homo sapiens
134 PMM1 5372
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 NUDT5 11164
Affinity Capture-MS Homo sapiens
136 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
137 CCRN4L  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DUSP14 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here