Gene description for USP6NL
Gene name USP6 N-terminal like
Gene symbol USP6NL
Other names/aliases RNTRE
TRE2NL
USP6NL-IT1
Species Homo sapiens
 Database cross references - USP6NL
ExoCarta ExoCarta_9712
Entrez Gene 9712
HGNC 16858
MIM 605405
UniProt Q92738  
 USP6NL identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for USP6NL
Molecular Function
    GTPase activator activity GO:0005096 IDA
    Rab GTPase binding GO:0017137 IPI
Biological Process
    regulation of cilium assembly GO:1902017 IMP
    regulation of Golgi organization GO:1903358 IMP
    positive regulation of GTPase activity GO:0043547 IEA
    retrograde transport, plasma membrane to Golgi GO:0035526 IMP
    Golgi organization GO:0007030 IMP
    plasma membrane to endosome transport GO:0048227 IMP
    virion assembly GO:0019068 IMP
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IDA
    plasma membrane GO:0005886 IDA
    Golgi apparatus GO:0005794 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
 Experiment description of studies that identified USP6NL in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for USP6NL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EPS8 2059
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
2 GRB2 2885
Invivo Homo sapiens
Invitro Homo sapiens
3 ACTN4 81
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which USP6NL is involved
No pathways found





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