Gene description for FGFR2
Gene name fibroblast growth factor receptor 2
Gene symbol FGFR2
Other names/aliases BBDS
BEK
BFR-1
CD332
CEK3
CFD1
ECT1
JWS
K-SAM
KGFR
TK14
TK25
Species Homo sapiens
 Database cross references - FGFR2
ExoCarta ExoCarta_2263
Entrez Gene 2263
HGNC 3689
MIM 176943
UniProt P21802  
 FGFR2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FGFR2
Molecular Function
    fibroblast growth factor binding GO:0017134 IPI
    protein tyrosine kinase activity GO:0004713 NAS
    heparin binding GO:0008201 IEA
    ATP binding GO:0005524 IEA
    fibroblast growth factor-activated receptor activity GO:0005007 NAS
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    lung development GO:0030324 ISS
    regulation of branching involved in prostate gland morphogenesis GO:0060687 ISS
    positive regulation of phospholipase activity GO:0010518 IMP
    organ morphogenesis GO:0009887 ISS
    positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 ISS
    angiogenesis GO:0001525 ISS
    epidermis morphogenesis GO:0048730 ISS
    multicellular organism growth GO:0035264 ISS
    epithelial cell differentiation GO:0030855 ISS
    positive regulation of cell cycle GO:0045787 ISS
    lateral sprouting from an epithelium GO:0060601 ISS
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow GO:0035602 ISS
    protein autophosphorylation GO:0046777 IDA
    fibroblast growth factor receptor signaling pathway involved in hemopoiesis GO:0035603 ISS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    innate immune response GO:0045087 TAS
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    bone mineralization GO:0030282 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    ventricular cardiac muscle tissue morphogenesis GO:0055010 ISS
    negative regulation of mitotic nuclear division GO:0045839 IEA
    regulation of ERK1 and ERK2 cascade GO:0070372 ISS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    pyramidal neuron development GO:0021860 ISS
    lacrimal gland development GO:0032808 ISS
    mesenchymal cell proliferation involved in lung development GO:0060916 ISS
    bud elongation involved in lung branching GO:0060449 ISS
    neuromuscular junction development GO:0007528 IEA
    coronal suture morphogenesis GO:0060365 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 ISS
    embryonic cranial skeleton morphogenesis GO:0048701 IMP
    squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0060529 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    embryonic pattern specification GO:0009880 ISS
    branching involved in labyrinthine layer morphogenesis GO:0060670 ISS
    epithelial to mesenchymal transition GO:0001837 IEA
    odontogenesis GO:0042476 ISS
    branching morphogenesis of a nerve GO:0048755 ISS
    mesenchymal cell differentiation involved in lung development GO:0060915 ISS
    epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 ISS
    lens fiber cell development GO:0070307 IEA
    embryonic digestive tract morphogenesis GO:0048557 ISS
    inner ear morphogenesis GO:0042472 ISS
    branching involved in prostate gland morphogenesis GO:0060442 ISS
    reproductive structure development GO:0048608 ISS
    outflow tract septum morphogenesis GO:0003148 ISS
    cell fate commitment GO:0045165 ISS
    prostate epithelial cord elongation GO:0060523 ISS
    regulation of fibroblast growth factor receptor signaling pathway GO:0040036 ISS
    in utero embryonic development GO:0001701 ISS
    post-embryonic development GO:0009791 ISS
    positive regulation of cardiac muscle cell proliferation GO:0060045 ISS
    regulation of osteoblast differentiation GO:0045667 TAS
    digestive tract development GO:0048565 ISS
    mesenchymal cell differentiation GO:0048762 ISS
    positive regulation of Wnt signaling pathway GO:0030177 ISS
    regulation of osteoblast proliferation GO:0033688 TAS
    synaptic vesicle transport GO:0048489 IEA
    positive regulation of mesenchymal cell proliferation GO:0002053 ISS
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISS
    positive regulation of cell division GO:0051781 ISS
    organ growth GO:0035265 ISS
    regulation of multicellular organism growth GO:0040014 ISS
    orbitofrontal cortex development GO:0021769 ISS
    ureteric bud development GO:0001657 ISS
    regulation of smooth muscle cell differentiation GO:0051150 ISS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    membranous septum morphogenesis GO:0003149 ISS
    regulation of smoothened signaling pathway GO:0008589 ISS
    branch elongation involved in salivary gland morphogenesis GO:0060667 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 ISS
    mesodermal cell differentiation GO:0048333 IEA
    lung-associated mesenchyme development GO:0060484 ISS
    mammary gland bud formation GO:0060615 ISS
    branching involved in salivary gland morphogenesis GO:0060445 ISS
    embryonic organ morphogenesis GO:0048562 ISS
    gland morphogenesis GO:0022612 ISS
    otic vesicle formation GO:0030916 ISS
    positive regulation of MAPK cascade GO:0043410 IMP
    hair follicle morphogenesis GO:0031069 ISS
    positive regulation of epithelial cell proliferation GO:0050679 ISS
    regulation of morphogenesis of a branching structure GO:0060688 ISS
    morphogenesis of embryonic epithelium GO:0016331 ISS
    prostate gland morphogenesis GO:0060512 ISS
    embryonic organ development GO:0048568 ISS
    cell-cell signaling GO:0007267 ISS
    positive regulation of cell proliferation GO:0008284 IMP
    bone development GO:0060348 ISS
    skeletal system morphogenesis GO:0048705 TAS
    lung lobe morphogenesis GO:0060463 ISS
    fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow GO:0035604 ISS
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    insulin receptor signaling pathway GO:0008286 TAS
    limb bud formation GO:0060174 ISS
    bone morphogenesis GO:0060349 ISS
    midbrain development GO:0030901 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    ventricular zone neuroblast division GO:0021847 ISS
    apoptotic process GO:0006915 IEA
    regulation of cell fate commitment GO:0010453 ISS
    lung alveolus development GO:0048286 ISS
    axonogenesis GO:0007409 ISS
    endodermal digestive tract morphogenesis GO:0061031 IEA
Subcellular Localization
    extracellular matrix GO:0031012 IDA
    integral component of membrane GO:0016021 NAS
    extracellular region GO:0005576 IEA
    nucleoplasm GO:0005654 IDA
    cell surface GO:0009986 IDA
    nucleus GO:0005634 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    integral component of plasma membrane GO:0005887 IDA
    membrane GO:0016020 NAS
    cytoplasm GO:0005737 IDA
    cell cortex GO:0005938 IDA
    plasma membrane GO:0005886 TAS
    excitatory synapse GO:0060076 ISS
    Golgi apparatus GO:0005794 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified FGFR2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FGFR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FGFR2 2263
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
2 FGF5  
Invivo Homo sapiens
3 PLCG1 5335
Invivo Homo sapiens
4 FGF1  
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
5 FGF10  
Invivo Homo sapiens
Invitro Homo sapiens
6 FGF2 2247
Invivo Homo sapiens
7 CACNA1D  
Invivo Homo sapiens
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