Gene description for CRLF2
Gene name cytokine receptor-like factor 2
Gene symbol CRLF2
Other names/aliases CRL2
CRLF2Y
TSLPR
Species Homo sapiens
 Database cross references - CRLF2
ExoCarta ExoCarta_64109
Vesiclepedia VP_64109
Entrez Gene 64109
HGNC 14281
MIM 300357
UniProt Q9HC73  
 CRLF2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CRLF2
Molecular Function
    cytokine receptor activity GO:0004896 IBA
    cytokine receptor activity GO:0004896 IDA
    cytokine receptor activity GO:0004896 IMP
    coreceptor activity GO:0015026 IDA
    cytokine binding GO:0019955 IBA
Biological Process
    positive regulation of cell population proliferation GO:0008284 IBA
    positive regulation of cell population proliferation GO:0008284 IDA
    cytokine-mediated signaling pathway GO:0019221 IBA
    cytokine-mediated signaling pathway GO:0019221 IDA
    positive regulation of interleukin-5 production GO:0032754 IMP
    positive regulation of mast cell activation GO:0033005 IMP
    positive regulation of receptor signaling pathway via STAT GO:1904894 IDA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    receptor complex GO:0043235 IBA
 Experiment description of studies that identified CRLF2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CRLF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 ADAM10 102
Affinity Capture-MS Homo sapiens
3 BCAM 4059
Affinity Capture-MS Homo sapiens
4 TEX13B  
Affinity Capture-MS Homo sapiens
5 ACVR2A  
Affinity Capture-MS Homo sapiens
6 SUSD1 64420
Affinity Capture-MS Homo sapiens
7 FGFR1 2260
Affinity Capture-MS Homo sapiens
8 MFAP3  
Affinity Capture-MS Homo sapiens
9 FGFR3 2261
Affinity Capture-MS Homo sapiens
10 SLC9A1 6548
Affinity Capture-MS Homo sapiens
11 TMED4 222068
Affinity Capture-MS Homo sapiens
12 STK39 27347
Affinity Capture-MS Homo sapiens
13 LRFN3  
Affinity Capture-MS Homo sapiens
14 SLC26A2 1836
Affinity Capture-MS Homo sapiens
15 SLC39A11  
Affinity Capture-MS Homo sapiens
16 STIM1 6786
Affinity Capture-MS Homo sapiens
17 FUT8 2530
Affinity Capture-MS Homo sapiens
18 UGCG 7357
Affinity Capture-MS Homo sapiens
19 TMEM59L  
Affinity Capture-MS Homo sapiens
20 ANTXR1 84168
Affinity Capture-MS Homo sapiens
21 PODXL2 50512
Affinity Capture-MS Homo sapiens
22 ITPRIP  
Affinity Capture-MS Homo sapiens
23 BMPR1A 657
Affinity Capture-MS Homo sapiens
24 ST6GALNAC3  
Affinity Capture-MS Homo sapiens
25 DCAKD 79877
Affinity Capture-MS Homo sapiens
26 ARL8B 55207
Affinity Capture-MS Homo sapiens
27 PRKDC 5591
Affinity Capture-MS Homo sapiens
28 HS6ST1  
Affinity Capture-MS Homo sapiens
29 FAM69A 388650
Affinity Capture-MS Homo sapiens
30 IFNGR1 3459
Affinity Capture-MS Homo sapiens
31 FGFR2 2263
Affinity Capture-MS Homo sapiens
32 ITFG1 81533
Affinity Capture-MS Homo sapiens
33 ACVR1B 91
Affinity Capture-MS Homo sapiens
34 TAMM41  
Affinity Capture-MS Homo sapiens
35 MAN2A2 4122
Affinity Capture-MS Homo sapiens
36 SPPL2B 56928
Affinity Capture-MS Homo sapiens
37 PIGB  
Affinity Capture-MS Homo sapiens
38 MPZL1 9019
Affinity Capture-MS Homo sapiens
39 STIM2 57620
Affinity Capture-MS Homo sapiens
40 MET 4233
Affinity Capture-MS Homo sapiens
41 NETO2  
Affinity Capture-MS Homo sapiens
42 CPD 1362
Affinity Capture-MS Homo sapiens
43 LMF2 91289
Affinity Capture-MS Homo sapiens
44 SEMA4F  
Affinity Capture-MS Homo sapiens
45 FGFR4 2264
Affinity Capture-MS Homo sapiens
46 MTX3  
Affinity Capture-MS Homo sapiens
47 WDR44 54521
Affinity Capture-MS Homo sapiens
48 ABHD17B 51104
Affinity Capture-MS Homo sapiens
49 PLXNA2 5362
Affinity Capture-MS Homo sapiens
50 ABHD14A  
Affinity Capture-MS Homo sapiens
51 METTL15  
Affinity Capture-MS Homo sapiens
52 ZDHHC13 54503
Affinity Capture-MS Homo sapiens
53 COA1  
Affinity Capture-MS Homo sapiens
54 JAK1 3716
Affinity Capture-MS Homo sapiens
55 NMU  
Affinity Capture-MS Homo sapiens
56 EPHB4 2050
Affinity Capture-MS Homo sapiens
57 SLC25A46 91137
Affinity Capture-MS Homo sapiens
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