Gene description for FAM69A
Gene name family with sequence similarity 69, member A
Gene symbol FAM69A
Other names/aliases -
Species Homo sapiens
 Database cross references - FAM69A
ExoCarta ExoCarta_388650
Vesiclepedia VP_388650
Entrez Gene 388650
HGNC 32213
MIM 614542
UniProt Q5T7M9  
 FAM69A identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FAM69A
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified FAM69A in sEVs
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FAM69A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 POMT2  
Affinity Capture-MS Homo sapiens
3 HFE  
Affinity Capture-MS Homo sapiens
4 CACNA2D1 781
Affinity Capture-MS Homo sapiens
5 CHRNA4  
Affinity Capture-MS Homo sapiens
6 CD3D 915
Affinity Capture-MS Homo sapiens
7 CACNA2D2 9254
Affinity Capture-MS Homo sapiens
8 HPN  
Affinity Capture-MS Homo sapiens
9 PACSIN2 11252
Affinity Capture-MS Homo sapiens
10 LRRC52  
Affinity Capture-MS Homo sapiens
11 CLEC2B  
Affinity Capture-MS Homo sapiens
12 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KLRC1  
Affinity Capture-MS Homo sapiens
14 ST14 6768
Affinity Capture-MS Homo sapiens
15 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 KLRC2  
Affinity Capture-MS Homo sapiens
18 RAB6B 51560
Affinity Capture-MS Homo sapiens
19 TMEM106A  
Affinity Capture-MS Homo sapiens
20 TMEM59 9528
Affinity Capture-MS Homo sapiens
21 HTR3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CNNM1  
Affinity Capture-MS Homo sapiens
23 TMED6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CLEC12B  
Affinity Capture-MS Homo sapiens
26 GGT7 2686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 LCTL  
Affinity Capture-MS Homo sapiens
28 TMEM219  
Affinity Capture-MS Homo sapiens
29 UGT1A5  
Affinity Capture-MS Homo sapiens
30 CHRNB2  
Affinity Capture-MS Homo sapiens
31 PBXIP1 57326
Affinity Capture-MS Homo sapiens
32 CD1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TCTN2  
Affinity Capture-MS Homo sapiens
34 CHST15 51363
Affinity Capture-MS Homo sapiens
35 TMEM259 91304
Affinity Capture-MS Homo sapiens
36 IL17RC 84818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ANKRD44 91526
Affinity Capture-MS Homo sapiens
38 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 DICER1  
Affinity Capture-MS Homo sapiens
40 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PNLDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CLRN2  
Affinity Capture-MS Homo sapiens
43 LRRC8A 56262
Affinity Capture-MS Homo sapiens
44 C15orf32  
Affinity Capture-MS Homo sapiens
45 UPK2 7379
Affinity Capture-MS Homo sapiens
46 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 GPIHBP1  
Affinity Capture-MS Homo sapiens
49 GRIA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SGPL1 8879
Affinity Capture-MS Homo sapiens
51 SUSD1 64420
Affinity Capture-MS Homo sapiens
52 HSD11B1 3290
Affinity Capture-MS Homo sapiens
53 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SEL1L3  
Affinity Capture-MS Homo sapiens
55 IL22RA1 58985
Affinity Capture-MS Homo sapiens
56 PLTP 5360
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
58 SLC3A2 6520
Affinity Capture-MS Homo sapiens
59 A4GNT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 PSCA 8000
Affinity Capture-MS Homo sapiens
61 ABCA2 20
Affinity Capture-MS Homo sapiens
62 FAM69B  
Affinity Capture-MS Homo sapiens
63 RNF185  
Affinity Capture-MS Homo sapiens
64 B3GALT5  
Affinity Capture-MS Homo sapiens
65 CRLF2 64109
Affinity Capture-MS Homo sapiens
66 ABHD16A 7920
Affinity Capture-MS Homo sapiens
67 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
68 GP9 2815
Affinity Capture-MS Homo sapiens
69 TXNDC15  
Affinity Capture-MS Homo sapiens
70 IGHD  
Affinity Capture-MS Homo sapiens
71 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 KEAP1 9817
Negative Genetic Homo sapiens
73 CD1B 910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 CHST5  
Affinity Capture-MS Homo sapiens
75 GOLPH3 64083
Affinity Capture-MS Homo sapiens
76 B4GAT1 11041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 LRP12 29967
Affinity Capture-MS Homo sapiens
78 BIRC6 57448
Affinity Capture-MS Homo sapiens
79 TLR9  
Affinity Capture-MS Homo sapiens
80 SCN4A  
Affinity Capture-MS Homo sapiens
81 TMUB2  
Affinity Capture-MS Homo sapiens
82 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
83 ARSG 22901
Affinity Capture-MS Homo sapiens
84 POMK  
Affinity Capture-MS Homo sapiens
85 NCEH1 57552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 MARCH4  
Affinity Capture-MS Homo sapiens
87 CHRNE  
Affinity Capture-MS Homo sapiens
88 CHRNA3 1136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM69A is involved
No pathways found





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