Gene description for BIRC6
Gene name baculoviral IAP repeat containing 6
Gene symbol BIRC6
Other names/aliases APOLLON
BRUCE
Species Homo sapiens
 Database cross references - BIRC6
ExoCarta ExoCarta_57448
Entrez Gene 57448
HGNC 13516
MIM 605638
UniProt Q9NR09  
 BIRC6 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Hepatocytes 26054723    
 Gene ontology annotations for BIRC6
Molecular Function
    cysteine-type endopeptidase inhibitor activity GO:0004869 IMP
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    ligase activity GO:0016874 IEA
Biological Process
    positive regulation of cell proliferation GO:0008284 IEA
    mitotic nuclear division GO:0007067 IEA
    negative regulation of apoptotic process GO:0043066 TAS
    protein ubiquitination GO:0016567 TAS
    cell division GO:0051301 IEA
    protein phosphorylation GO:0006468 TAS
    apoptotic process GO:0006915 IEA
    labyrinthine layer development GO:0060711 IEA
    spongiotrophoblast layer development GO:0060712 IEA
    negative regulation of endopeptidase activity GO:0010951 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    regulation of cell proliferation GO:0042127 TAS
    regulation of cytokinesis GO:0032465 IMP
Subcellular Localization
    spindle pole GO:0000922 IDA
    endosome GO:0005768 IDA
    trans-Golgi network GO:0005802 IDA
    membrane GO:0016020 IDA
    microtubule organizing center GO:0005815 IDA
    midbody GO:0030496 IDA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified BIRC6 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for BIRC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF41  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BIRC6 is involved
No pathways found





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