Gene description for TOR2A
Gene name torsin family 2, member A
Gene symbol TOR2A
Other names/aliases TORP1
Species Homo sapiens
 Database cross references - TOR2A
ExoCarta ExoCarta_27433
Vesiclepedia VP_27433
Entrez Gene 27433
HGNC 11996
MIM 608052
UniProt Q8N2E6   Q5JU69  
 TOR2A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TOR2A
Molecular Function
    hormone activity GO:0005179 IDA
    hormone activity GO:0005179 IEA
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    identical protein binding GO:0042802 IPI
Biological Process
    signal transduction GO:0007165 IEA
    cell-cell signaling GO:0007267 IDA
    positive regulation of gene expression GO:0010628 IDA
    vasopressin secretion GO:0030103 IDA
    killing of cells of another organism GO:0031640 IMP
    positive regulation of cAMP-mediated signaling GO:0043950 IDA
    chaperone cofactor-dependent protein refolding GO:0051085 IEA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IC
    positive regulation of calcium ion transmembrane transport GO:1904427 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 IEA
    nuclear envelope GO:0005635 IBA
    cytoplasm GO:0005737 IEA
    endoplasmic reticulum lumen GO:0005788 IBA
    endoplasmic reticulum lumen GO:0005788 IDA
    endomembrane system GO:0012505 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
 Experiment description of studies that identified TOR2A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TOR2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HPN  
Affinity Capture-MS Homo sapiens
2 C7orf34  
Affinity Capture-MS Homo sapiens
3 ALPI  
Affinity Capture-MS Homo sapiens
4 ZNF708  
Affinity Capture-MS Homo sapiens
5 ZNF707  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LCN2 3934
Affinity Capture-MS Homo sapiens
7 HSPA5 3309
Affinity Capture-MS Homo sapiens
8 ST14 6768
Affinity Capture-MS Homo sapiens
9 CUL3 8452
Affinity Capture-MS Homo sapiens
10 TOR1A 1861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TTC19  
Affinity Capture-MS Homo sapiens
12 CTBP1 1487
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ENOPH1 58478
Affinity Capture-MS Homo sapiens
14 BIRC6 57448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 GPR50  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TOR2A is involved
No pathways found





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