Gene description for TOR1A
Gene name torsin family 1, member A (torsin A)
Gene symbol TOR1A
Other names/aliases DQ2
Species Homo sapiens
 Database cross references - TOR1A
ExoCarta ExoCarta_1861
Entrez Gene 1861
HGNC 3098
MIM 605204
UniProt O14656  
 TOR1A identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for TOR1A
Molecular Function
    protein binding GO:0005515 IPI
    unfolded protein binding GO:0051082 IEA
    cytoskeletal protein binding GO:0008092 IPI
    ATPase activity GO:0016887 IDA
    ATP binding GO:0005524 IEA
    kinesin binding GO:0019894 IPI
    misfolded protein binding GO:0051787 IEA
Biological Process
    protein homooligomerization GO:0051260 IDA
    wound healing, spreading of cells GO:0044319 ISS
    nuclear envelope organization GO:0006998 ISS
    nuclear membrane organization GO:0071763 ISS
    regulation of protein localization to cell surface GO:2000008 IMP
    synaptic vesicle transport GO:0048489 IMP
    cell adhesion GO:0007155 IMP
    ER-associated misfolded protein catabolic process GO:0071712 ISS
    chaperone-mediated protein transport GO:0072321 IDA
    protein deneddylation GO:0000338 IMP
    response to oxidative stress GO:0006979 IEA
    protein localization to nucleus GO:0034504 ISS
    positive regulation of synaptic vesicle endocytosis GO:1900244 IMP
    chaperone mediated protein folding requiring cofactor GO:0051085 IEA
    organelle organization GO:0006996 ISS
    regulation of dopamine uptake involved in synaptic transmission GO:0051584 IDA
    neuron projection development GO:0031175 IMP
    intermediate filament cytoskeleton organization GO:0045104 IMP
    chaperone-mediated protein folding GO:0061077 IDA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    membrane GO:0016020 IDA
    transport vesicle GO:0030133 IEA
    growth cone GO:0030426 ISS
    extrinsic component of endoplasmic reticulum membrane GO:0042406 IDA
    synaptic vesicle GO:0008021 IDA
    endoplasmic reticulum lumen GO:0005788 IDA
    nuclear membrane GO:0031965 IDA
    nuclear envelope GO:0005635 ISS
    cytoplasmic vesicle membrane GO:0030659 ISS
    cell junction GO:0030054 IEA
    extracellular exosome GO:0070062 IDA
    secretory granule GO:0030141 ISS
    endoplasmic reticulum GO:0005783 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified TOR1A in exosomes
Experiment ID 66
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TOR1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPC163  
Affinity Capture-MS Homo sapiens
2 TOR1B 27348
Affinity Capture-Western Homo sapiens
3 DHCR7 1717
Affinity Capture-MS Homo sapiens
4 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
5 SNCA 6622
FRET Homo sapiens
View the network image/svg+xml
 Pathways in which TOR1A is involved
No pathways found

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