Gene description for TOR1B
Gene name torsin family 1, member B (torsin B)
Gene symbol TOR1B
Other names/aliases DQ1
Species Homo sapiens
 Database cross references - TOR1B
ExoCarta ExoCarta_27348
Entrez Gene 27348
HGNC 11995
MIM 608050
UniProt O14657  
 TOR1B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Saliva 19199708    
 Gene ontology annotations for TOR1B
Molecular Function
    protein binding GO:0005515 IPI
    ATPase activity GO:0016887 IDA
    ATP binding GO:0005524 IEA
Biological Process
    response to unfolded protein GO:0006986 TAS
    nuclear membrane organization GO:0071763 IEA
    protein homooligomerization GO:0051260 IDA
    chaperone mediated protein folding requiring cofactor GO:0051085 IEA
    endoplasmic reticulum organization GO:0007029 IDA
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IDA
    nuclear envelope GO:0005635 IDA
    nuclear membrane GO:0031965 IEA
    endoplasmic reticulum GO:0005783 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified TOR1B in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TOR1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOR1A 1861
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TOR1B is involved
No pathways found





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