Gene description for MFAP4
Gene name microfibrillar-associated protein 4
Gene symbol MFAP4
Other names/aliases -
Species Homo sapiens
 Database cross references - MFAP4
ExoCarta ExoCarta_4239
Entrez Gene 4239
HGNC 7035
MIM 600596
UniProt P55083  
 MFAP4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MFAP4
Molecular Function
    protein binding GO:0005515 IPI
    molecular_function GO:0003674 ND
Biological Process
    regulation of collagen metabolic process GO:0010712 IDA
    UV protection GO:0009650 IDA
    cellular response to UV-B GO:0071493 IDA
    extracellular matrix organization GO:0030198 TAS
    cell adhesion GO:0007155 IEA
    extracellular fibril organization GO:0043206 IDA
    elastic fiber assembly GO:0048251 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    microfibril GO:0001527 NAS
    extracellular matrix GO:0031012 IDA
    elastic fiber GO:0071953 IDA
 Experiment description of studies that identified MFAP4 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MFAP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFTPD  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which MFAP4 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres TAS Reactome





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