Gene description for MFAP4
Gene name microfibrillar-associated protein 4
Gene symbol MFAP4
Other names/aliases -
Species Homo sapiens
 Database cross references - MFAP4
ExoCarta ExoCarta_4239
Vesiclepedia VP_4239
Entrez Gene 4239
HGNC 7035
MIM 600596
UniProt P55083  
 MFAP4 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MFAP4
Molecular Function
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    UV protection GO:0009650 IDA
    regulation of collagen metabolic process GO:0010712 IDA
    elastic fiber assembly GO:0048251 IBA
    elastic fiber assembly GO:0048251 IDA
    cellular response to UV-B GO:0071493 IDA
    supramolecular fiber organization GO:0097435 IDA
Subcellular Localization
    microfibril GO:0001527 IDA
    microfibril GO:0001527 NAS
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IDA
    elastic fiber GO:0071953 IDA
 Experiment description of studies that identified MFAP4 in exosomes
1
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MFAP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SSBP4  
Affinity Capture-MS Homo sapiens
2 NOMO1 23420
Affinity Capture-MS Homo sapiens
3 UGGT2 55757
Affinity Capture-MS Homo sapiens
4 SGSH 6448
Affinity Capture-MS Homo sapiens
5 VPS35 55737
Affinity Capture-MS Homo sapiens
6 OCLN 100506658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CACNA2D2 9254
Affinity Capture-MS Homo sapiens
8 IDUA 3425
Affinity Capture-MS Homo sapiens
9 AES 166
Affinity Capture-MS Homo sapiens
10 SEMA6B 10501
Affinity Capture-MS Homo sapiens
11 FKBP15 23307
Affinity Capture-MS Homo sapiens
12 TUBB8 347688
Affinity Capture-MS Homo sapiens
13 ARSB 411
Affinity Capture-MS Homo sapiens
14 LMX1B  
Affinity Capture-MS Homo sapiens
15 TNFRSF6B  
Affinity Capture-MS Homo sapiens
16 THSD4 79875
Affinity Capture-MS Homo sapiens
17 SOX2  
Affinity Capture-MS Homo sapiens
18 ADAM19 8728
Affinity Capture-MS Homo sapiens
19 POMGNT2  
Affinity Capture-MS Homo sapiens
20 PEX1 5189
Affinity Capture-MS Homo sapiens
21 FGFR3 2261
Affinity Capture-MS Homo sapiens
22 APEX1 328
Affinity Capture-RNA Homo sapiens
23 SUN2 25777
Affinity Capture-MS Homo sapiens
24 MGAT5 4249
Affinity Capture-MS Homo sapiens
25 UXS1 80146
Affinity Capture-MS Homo sapiens
26 SCARA3  
Affinity Capture-MS Homo sapiens
27 PLAU 5328
Affinity Capture-MS Homo sapiens
28 CEMIP 57214
Affinity Capture-MS Homo sapiens
29 ADGRG1 9289
Affinity Capture-MS Homo sapiens
30 HYAL2 8692
Affinity Capture-MS Homo sapiens
31 MMP15 4324
Affinity Capture-MS Homo sapiens
32 ERC1 23085
Affinity Capture-MS Homo sapiens
33 OAF 220323
Affinity Capture-MS Homo sapiens
34 SEPN1 57190
Affinity Capture-MS Homo sapiens
35 COL18A1 80781
Affinity Capture-MS Homo sapiens
36 PCSK6 5046
Affinity Capture-MS Homo sapiens
37 SLC25A46 91137
Affinity Capture-MS Homo sapiens
38 GUSB 2990
Affinity Capture-MS Homo sapiens
39 IL17RA 23765
Affinity Capture-MS Homo sapiens
40 GPX8 493869
Affinity Capture-MS Homo sapiens
41 TLL2  
Affinity Capture-MS Homo sapiens
42 P3H4 10609
Affinity Capture-MS Homo sapiens
43 GCA 25801
Affinity Capture-MS Homo sapiens
44 NXPH4  
Affinity Capture-MS Homo sapiens
45 MELK  
Affinity Capture-MS Homo sapiens
46 CHST12 55501
Affinity Capture-MS Homo sapiens
47 CHID1 66005
Affinity Capture-MS Homo sapiens
48 RPS4Y2 140032
Affinity Capture-MS Homo sapiens
49 AURKA 6790
Affinity Capture-MS Homo sapiens
50 Sftpd  
Reconstituted Complex Rattus norvegicus
51 TOR1B 27348
Affinity Capture-MS Homo sapiens
52 FUT8 2530
Affinity Capture-MS Homo sapiens
53 LRIG2  
Affinity Capture-MS Homo sapiens
54 UGT8  
Affinity Capture-MS Homo sapiens
55 RNF115  
Two-hybrid Homo sapiens
56 CHPF2 54480
Affinity Capture-MS Homo sapiens
57 CSPG4 1464
Affinity Capture-MS Homo sapiens
58 KDELC2 143888
Affinity Capture-MS Homo sapiens
59 PBXIP1 57326
Affinity Capture-MS Homo sapiens
60 CSTF3 1479
Affinity Capture-MS Homo sapiens
61 MAN2A2 4122
Affinity Capture-MS Homo sapiens
62 TIGD5  
Affinity Capture-MS Homo sapiens
63 LRPAP1 4043
Affinity Capture-MS Homo sapiens
64 THBS1 7057
Affinity Capture-MS Homo sapiens
65 TBC1D5 9779
Affinity Capture-MS Homo sapiens
66 P4HB 5034
Affinity Capture-MS Homo sapiens
67 LMF2 91289
Affinity Capture-MS Homo sapiens
68 ART5  
Affinity Capture-MS Homo sapiens
69 PLXNA3 55558
Affinity Capture-MS Homo sapiens
70 TMEM131  
Affinity Capture-MS Homo sapiens
71 CERCAM 51148
Affinity Capture-MS Homo sapiens
72 MBTPS1 8720
Affinity Capture-MS Homo sapiens
73 CHST14 113189
Affinity Capture-MS Homo sapiens
74 QSOX1 5768
Affinity Capture-MS Homo sapiens
75 CSTF1 1477
Affinity Capture-MS Homo sapiens
76 MAN2B2 23324
Affinity Capture-MS Homo sapiens
77 AGPAT1 10554
Affinity Capture-MS Homo sapiens
78 TLE2  
Affinity Capture-MS Homo sapiens
79 RDH13  
Affinity Capture-MS Homo sapiens
80 TLE3  
Affinity Capture-MS Homo sapiens
81 METRNL 284207
Affinity Capture-MS Homo sapiens
82 LRFN3  
Affinity Capture-MS Homo sapiens
83 LOXL2 4017
Affinity Capture-MS Homo sapiens
84 NAGLU 4669
Affinity Capture-MS Homo sapiens
85 LAMB3 3914
Affinity Capture-MS Homo sapiens
86 PPHLN1  
Affinity Capture-MS Homo sapiens
87 GALNT18  
Affinity Capture-MS Homo sapiens
88 TMEM132A 54972
Affinity Capture-MS Homo sapiens
89 CRLF1 9244
Affinity Capture-MS Homo sapiens
90 CHRD  
Affinity Capture-MS Homo sapiens
91 KCNAB2 8514
Affinity Capture-MS Homo sapiens
92 FAM208B 54906
Affinity Capture-MS Homo sapiens
93 TTC17 55761
Affinity Capture-MS Homo sapiens
94 HPSE 10855
Affinity Capture-MS Homo sapiens
95 DNAJC3 5611
Affinity Capture-MS Homo sapiens
96 P3H3 10536
Affinity Capture-MS Homo sapiens
97 PTPRU  
Affinity Capture-MS Homo sapiens
98 POGLUT1 56983
Affinity Capture-MS Homo sapiens
99 BMP1 649
Affinity Capture-MS Homo sapiens
100 CLEC16A  
Affinity Capture-MS Homo sapiens
101 ZNF589  
Affinity Capture-MS Homo sapiens
102 TTC13  
Affinity Capture-MS Homo sapiens
103 ADAMTS7  
Affinity Capture-MS Homo sapiens
104 LOXL1 4016
Affinity Capture-MS Homo sapiens
105 NAAA  
Affinity Capture-MS Homo sapiens
106 PLXNA2 5362
Affinity Capture-MS Homo sapiens
107 GRB2 2885
Affinity Capture-MS Homo sapiens
108 LDB1  
Affinity Capture-MS Homo sapiens
109 FOXRED2  
Affinity Capture-MS Homo sapiens
110 TP53 7157
Affinity Capture-MS Homo sapiens
111 METRN 79006
Affinity Capture-MS Homo sapiens
112 KDELC1 79070
Affinity Capture-MS Homo sapiens
113 GALNS 2588
Affinity Capture-MS Homo sapiens
114 SEMA3C 10512
Affinity Capture-MS Homo sapiens
115 PLXNA1 5361
Affinity Capture-MS Homo sapiens
116 TLE1 7088
Affinity Capture-MS Homo sapiens
117 SSBP2  
Affinity Capture-MS Homo sapiens
118 PRF1  
Affinity Capture-MS Homo sapiens
119 BDNF 627
Affinity Capture-MS Homo sapiens
120 EDEM3 80267
Affinity Capture-MS Homo sapiens
121 SSBP3  
Affinity Capture-MS Homo sapiens
122 TLE4  
Affinity Capture-MS Homo sapiens
123 SEMA3B 7869
Affinity Capture-MS Homo sapiens
124 NPTXR 23467
Affinity Capture-MS Homo sapiens
125 FUT11 170384
Affinity Capture-MS Homo sapiens
126 BMP8B  
Affinity Capture-MS Homo sapiens
127 LAMB2 3913
Affinity Capture-MS Homo sapiens
128 OLFM2  
Affinity Capture-MS Homo sapiens
129 LAMA5 3911
Affinity Capture-MS Homo sapiens
130 SFTPD  
Reconstituted Complex Bos taurus
131 ISL2  
Affinity Capture-MS Homo sapiens
132 ARSK  
Affinity Capture-MS Homo sapiens
133 CILP2  
Affinity Capture-MS Homo sapiens
134 HS6ST2 90161
Affinity Capture-MS Homo sapiens
135 DDX28  
Affinity Capture-MS Homo sapiens
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