Gene description for HPSE
Gene name	heparanase
Gene symbol	HPSE
Other names/aliases	HPA HPA1 HPR1 HPSE1 HSE1
Species	Homo sapiens
Database cross references - HPSE
ExoCarta	ExoCarta_10855
Entrez Gene	10855
HGNC	5164
MIM	604724
UniProt	Q9Y251
HPSE identified in exosomes derived from the following tissue/cell type
Malignant ascites	19188015
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for HPSE

Molecular Function     beta-glucuronidase activity GO:0004566 TAS     protein binding GO:0005515 IPI     syndecan binding GO:0045545 IDA     heparanase activity GO:0030305 TAS     protein dimerization activity GO:0046983 IDA Biological Process     heparan sulfate proteoglycan catabolic process GO:0030200 IDA     carbohydrate metabolic process GO:0005975 TAS     small molecule metabolic process GO:0044281 TAS     proteoglycan metabolic process GO:0006029 TAS     glycosaminoglycan metabolic process GO:0030203 TAS     positive regulation of protein kinase B signaling GO:0051897 IDA     positive regulation of vascular endothelial growth factor production GO:0010575 IDA     vascular wound healing GO:0061042 IEA     glycosaminoglycan catabolic process GO:0006027 TAS     positive regulation of blood coagulation GO:0030194 IDA     regulation of hair follicle development GO:0051797 IDA     cell-matrix adhesion GO:0007160 IDA     positive regulation of hair follicle development GO:0051798 IEA     positive regulation of osteoblast proliferation GO:0033690 IDA Subcellular Localization     membrane raft GO:0045121 IEA     nucleoplasm GO:0005654 IDA     lysosomal lumen GO:0043202 TAS     lysosomal membrane GO:0005765 IEA     nucleus GO:0005634 IDA     extracellular region GO:0005576 IEA     lysosome GO:0005764 IDA     intracellular membrane-bounded organelle GO:0043231 IDA