Gene description for HPSE
Gene name	heparanase
Gene symbol	HPSE
Other names/aliases	HPA HPA1 HPR1 HPSE1 HSE1
Species	Homo sapiens
Database cross references - HPSE
ExoCarta	ExoCarta_10855
Vesiclepedia	VP_10855
Entrez Gene	10855
HGNC	5164
MIM	604724
UniProt	Q9Y251
HPSE identified in sEVs derived from the following tissue/cell type
Malignant ascites	19188015
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for HPSE

Molecular Function     beta-glucuronidase activity GO:0004566 TAS     protein binding GO:0005515 IPI     heparanase activity GO:0030305 IDA     heparanase activity GO:0030305 IDA     syndecan binding GO:0045545 IDA Biological Process     proteoglycan metabolic process GO:0006029 TAS     cell-matrix adhesion GO:0007160 IBA     cell-matrix adhesion GO:0007160 IDA     positive regulation of vascular endothelial growth factor production GO:0010575 IDA     positive regulation of blood coagulation GO:0030194 IDA     heparan sulfate proteoglycan catabolic process GO:0030200 IDA     heparin metabolic process GO:0030202 IEA     positive regulation of osteoblast proliferation GO:0033690 IDA     response to antibiotic GO:0046677 IEA     regulation of hair follicle development GO:0051797 IDA     positive regulation of hair follicle development GO:0051798 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA     angiogenesis involved in wound healing GO:0060055 IBA     establishment of endothelial barrier GO:0061028 IEA     vascular wound healing GO:0061042 IEA     protein transmembrane transport GO:0071806 IEA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     lysosome GO:0005764 IDA     lysosomal membrane GO:0005765 IEA     extracellular matrix GO:0031012 IBA     specific granule lumen GO:0035580 TAS     lysosomal lumen GO:0043202 TAS     intracellular membrane-bounded organelle GO:0043231 IDA     membrane raft GO:0045121 IEA     heparanase complex GO:1904974 IDA