Gene description for KDELC2
Gene name KDEL (Lys-Asp-Glu-Leu) containing 2
Gene symbol KDELC2
Other names/aliases -
Species Homo sapiens
 Database cross references - KDELC2
ExoCarta ExoCarta_143888
Vesiclepedia VP_143888
Entrez Gene 143888
HGNC 28496
UniProt Q7Z4H8  
 KDELC2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for KDELC2
Molecular Function
    UDP-glucosyltransferase activity GO:0035251 IDA
    UDP-xylosyltransferase activity GO:0035252 IDA
    glucosyltransferase activity GO:0046527 IBA
    EGF-domain serine glucosyltransferase activity GO:0140561 IEA
    EGF-domain serine xylosyltransferase activity GO:0140562 IEA
Biological Process
    protein O-linked glycosylation via serine GO:0018242 IDA
    protein O-linked glycosylation via serine GO:0018242 IMP
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IEA
    endomembrane system GO:0012505 IBA
 Experiment description of studies that identified KDELC2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for KDELC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NIT2 56954
Co-fractionation Homo sapiens
2 GSTP1 2950
Co-fractionation Homo sapiens
3 ETHE1 23474
Co-fractionation Homo sapiens
4 C7orf34  
Affinity Capture-MS Homo sapiens
5 APOA1BP 128240
Co-fractionation Homo sapiens
6 CASP8AP2  
Cross-Linking-MS (XL-MS) Homo sapiens
7 ALDH7A1 501
Co-fractionation Homo sapiens
8 OGT 8473
Reconstituted Complex Homo sapiens
9 PMPCB 9512
Co-fractionation Homo sapiens
10 LILRA5  
Affinity Capture-MS Homo sapiens
11 NAAA  
Affinity Capture-MS Homo sapiens
12 PRSS50  
Affinity Capture-MS Homo sapiens
13 SOD2 6648
Co-fractionation Homo sapiens
14 SOD1 6647
Co-fractionation Homo sapiens
15 CANX 821
Affinity Capture-MS Homo sapiens
16 TP53 7157
Affinity Capture-MS Homo sapiens
17 CALR3  
Proximity Label-MS Homo sapiens
18 SEC61B 10952
Proximity Label-MS Homo sapiens
19 PDIA4 9601
Proximity Label-MS Homo sapiens
20 SNX27 81609
Affinity Capture-MS Homo sapiens
21 SUCLG2 8801
Co-fractionation Homo sapiens
22 CALU 813
Proximity Label-MS Homo sapiens
23 PPA1 5464
Co-fractionation Homo sapiens
24 CBLN4  
Affinity Capture-MS Homo sapiens
25 PDGFRA 5156
Affinity Capture-MS Homo sapiens
26 PRG2  
Affinity Capture-MS Homo sapiens
27 MFAP4 4239
Affinity Capture-MS Homo sapiens
28 SUCLG1 8802
Co-fractionation Homo sapiens
29 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SUCLA2 8803
Co-fractionation Homo sapiens
31 PRPF40A 55660
Cross-Linking-MS (XL-MS) Homo sapiens
32 C1QTNF7  
Affinity Capture-MS Homo sapiens
33 COA7  
Co-fractionation Homo sapiens
34 DECR1 1666
Co-fractionation Homo sapiens
35 HSPA5 3309
Affinity Capture-MS Homo sapiens
36 SP6  
Affinity Capture-MS Homo sapiens
37 GRHPR 9380
Co-fractionation Homo sapiens
38 CTSD 1509
Co-fractionation Homo sapiens
39 GSTO1 9446
Co-fractionation Homo sapiens
40 TMEM25  
Affinity Capture-MS Homo sapiens
41 SUSD4  
Affinity Capture-MS Homo sapiens
42 ABHD10 55347
Co-fractionation Homo sapiens
43 ACSF2 80221
Co-fractionation Homo sapiens
44 FBXO2 26232
Affinity Capture-MS Homo sapiens
45 PMPCA 23203
Co-fractionation Homo sapiens
46 SCGB2A2  
Affinity Capture-MS Homo sapiens
47 CCS 9973
Co-fractionation Homo sapiens
48 TPI1 7167
Co-fractionation Homo sapiens
49 ANXA5 308
Co-fractionation Homo sapiens
50 DNAJC3 5611
Proximity Label-MS Homo sapiens
51 ACTB 60
Co-fractionation Homo sapiens
52 CYB5A 1528
Co-fractionation Homo sapiens
53 TDGF1  
Affinity Capture-MS Homo sapiens
54 ENPP7 339221
Affinity Capture-MS Homo sapiens
55 ST8SIA5  
Affinity Capture-MS Homo sapiens
56 DRG2 1819
Cross-Linking-MS (XL-MS) Homo sapiens
57 BMP1 649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 LRRC59 55379
Proximity Label-MS Homo sapiens
59 VWA1 64856
Affinity Capture-MS Homo sapiens
60 AKAP1 8165
Proximity Label-MS Homo sapiens
61 FDX1L  
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which KDELC2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here