Gene description for CCS
Gene name copper chaperone for superoxide dismutase
Gene symbol CCS
Other names/aliases -
Species Homo sapiens
 Database cross references - CCS
ExoCarta ExoCarta_9973
Entrez Gene 9973
HGNC 1613
MIM 603864
UniProt O14618  
 CCS identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CCS
Molecular Function
    zinc ion binding GO:0008270 IBA
    copper ion binding GO:0005507 TAS
    protein binding GO:0005515 IPI
    protein disulfide oxidoreductase activity GO:0015035 TAS
    copper ion transmembrane transporter activity GO:0005375 TAS
    superoxide dismutase activity GO:0004784 IBA
Biological Process
    copper ion transmembrane transport GO:0035434 TAS
    removal of superoxide radicals GO:0019430 IBA
    positive regulation of oxidoreductase activity GO:0051353 IEA
    intracellular copper ion transport GO:0015680 TAS
    oxidation-reduction process GO:0055114 IEA
    superoxide metabolic process GO:0006801 TAS
    response to reactive oxygen species GO:0000302 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified CCS in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CCS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APBA1  
Invivo Homo sapiens
Invitro Homo sapiens
2 SOD1 6647
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CCS is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species TAS Reactome





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