Gene description for BMP1
Gene name bone morphogenetic protein 1
Gene symbol BMP1
Other names/aliases OI13
PCOLC
PCP
PCP2
TLD
Species Homo sapiens
 Database cross references - BMP1
ExoCarta ExoCarta_649
Vesiclepedia VP_649
Entrez Gene 649
HGNC 1067
MIM 112264
UniProt P13497  
 BMP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BMP1
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 TAS
    serine-type endopeptidase activity GO:0004252 TAS
    cytokine activity GO:0005125 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    peptidase activity GO:0008233 IDA
    metallopeptidase activity GO:0008237 NAS
    zinc ion binding GO:0008270 IEA
    identical protein binding GO:0042802 IPI
Biological Process
    skeletal system development GO:0001501 NAS
    cartilage condensation GO:0001502 TAS
    ossification GO:0001503 IEA
    proteolysis GO:0006508 IDA
    signal transduction GO:0007165 IEA
    dorsal/ventral pattern formation GO:0009953 IBA
    protein processing GO:0016485 IBA
    cell differentiation GO:0030154 IEA
    collagen fibril organization GO:0030199 TAS
    positive regulation of cartilage development GO:0061036 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    Golgi apparatus GO:0005794 IEA
    vesicle GO:0031982 IEA
 Experiment description of studies that identified BMP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BMP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 ZMYND19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 KLK15  
Affinity Capture-MS Homo sapiens
5 CLIP1 6249
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LCN6  
Affinity Capture-MS Homo sapiens
7 PAEP  
Affinity Capture-MS Homo sapiens
8 FSTL4  
Affinity Capture-MS Homo sapiens
9 CFC1  
Affinity Capture-MS Homo sapiens
10 MFAP4 4239
Affinity Capture-MS Homo sapiens
11 GID4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 KIF5A 3798
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 OIT3 170392
Affinity Capture-MS Homo sapiens
14 IGFBP4 3487
Affinity Capture-MS Homo sapiens
15 SLURP1  
Affinity Capture-MS Homo sapiens
16 WDR26 80232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 KLK2  
Affinity Capture-MS Homo sapiens
18 EPHA8  
Affinity Capture-MS Homo sapiens
19 INA 9118
Affinity Capture-MS Homo sapiens
20 BTLA  
Affinity Capture-MS Homo sapiens
21 RANBP10 57610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 OS9 10956
Affinity Capture-MS Homo sapiens
23 SMC2 10592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MKLN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 KIF2C 11004
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 GOLGA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CALR 811
Affinity Capture-MS Homo sapiens
28 ELSPBP1  
Affinity Capture-MS Homo sapiens
29 BTNL2  
Affinity Capture-MS Homo sapiens
30 TLL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 DVL2 1856
Affinity Capture-MS Homo sapiens
32 EEA1 8411
Affinity Capture-MS Homo sapiens
33 TRGV3  
Affinity Capture-MS Homo sapiens
34 SDF2 6388
Affinity Capture-MS Homo sapiens
35 MRE11A 4361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ARMC8 25852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NBN 4683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 MSTN  
Affinity Capture-MS Homo sapiens
39 MSMB  
Affinity Capture-MS Homo sapiens
40 GEM  
Two-hybrid Homo sapiens
41 KDELC2 143888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CSTF3 1479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FIBIN  
Affinity Capture-MS Homo sapiens
44 GID8 54994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CRISP2  
Affinity Capture-MS Homo sapiens
46 DNAJB9 4189
Affinity Capture-MS Homo sapiens
47 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
48 PRKAR1B  
Affinity Capture-MS Homo sapiens
49 SDF2L1 23753
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 LYPD4  
Affinity Capture-MS Homo sapiens
51 PDGFRA 5156
Affinity Capture-MS Homo sapiens
52 PRKACB 5567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RAD21 5885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RMND5A 64795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 LY86  
Affinity Capture-MS Homo sapiens
56 C7orf34  
Affinity Capture-MS Homo sapiens
57 GPIHBP1  
Affinity Capture-MS Homo sapiens
58 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CSTF1 1477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MAD1L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 GGH 8836
Affinity Capture-MS Homo sapiens
63 PON2 5445
Affinity Capture-MS Homo sapiens
64 WDR25  
Affinity Capture-MS Homo sapiens
65 PRG2  
Affinity Capture-MS Homo sapiens
66 PI15  
Affinity Capture-MS Homo sapiens
67 CBLN4  
Affinity Capture-MS Homo sapiens
68 LYZL1  
Affinity Capture-MS Homo sapiens
69 IL5RA  
Affinity Capture-MS Homo sapiens
70 EPHA7 2045
Affinity Capture-MS Homo sapiens
71 RANBP9 10048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 FASN 2194
Negative Genetic Homo sapiens
73 C1QB 713
Affinity Capture-MS Homo sapiens
74 Uso1 56041
Affinity Capture-MS Mus musculus
75 FBXO2 26232
Affinity Capture-MS Homo sapiens
76 ZNF213  
Affinity Capture-MS Homo sapiens
77 SCGB2A2  
Affinity Capture-MS Homo sapiens
78 MYCN  
Affinity Capture-MS Homo sapiens
79 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
80 CHRD  
Biochemical Activity Homo sapiens
81 NCAPG 64151
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 TLL1 7092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CA6 765
Affinity Capture-MS Homo sapiens
84 BCAN  
Affinity Capture-MS Homo sapiens
85 TP53 7157
Two-hybrid Homo sapiens
86 KDELC1 79070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 PRSS2 5645
Affinity Capture-MS Homo sapiens
88 RMND5B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 NCR3  
Affinity Capture-MS Homo sapiens
90 RAD50 10111
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 NCAPD2 9918
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 ADIPOQ 9370
Affinity Capture-MS Homo sapiens
93 KLHL22 84861
Affinity Capture-MS Homo sapiens
94 CST11  
Affinity Capture-MS Homo sapiens
95 EDN3  
Affinity Capture-MS Homo sapiens
96 MAEA 10296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 GREM2 64388
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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