Gene description for CA6
Gene name carbonic anhydrase VI
Gene symbol CA6
Other names/aliases CA-VI
GUSTIN
Species Homo sapiens
 Database cross references - CA6
ExoCarta ExoCarta_765
Entrez Gene 765
HGNC 1380
MIM 114780
UniProt P23280  
 CA6 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for CA6
Molecular Function
    zinc ion binding GO:0008270 IEA
    carbonate dehydratase activity GO:0004089 TAS
Biological Process
    one-carbon metabolic process GO:0006730 IEA
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 IDA
    bicarbonate transport GO:0015701 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
    cytoplasm GO:0005737 IEA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CA6 in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for CA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CA6 is involved
PathwayEvidenceSource
Reversible hydration of carbon dioxide TAS Reactome





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