Gene description for CA6
Gene name carbonic anhydrase VI
Gene symbol CA6
Other names/aliases CA-VI
GUSTIN
Species Homo sapiens
 Database cross references - CA6
ExoCarta ExoCarta_765
Vesiclepedia VP_765
Entrez Gene 765
HGNC 1380
MIM 114780
UniProt P23280  
 CA6 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for CA6
Molecular Function
    carbonate dehydratase activity GO:0004089 IBA
    zinc ion binding GO:0008270 IEA
Biological Process
    detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    cytosol GO:0005829 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CA6 in exosomes
1
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for CA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR2 23304
Affinity Capture-MS Homo sapiens
2 PEX6  
Affinity Capture-MS Homo sapiens
3 HKDC1 80201
Affinity Capture-MS Homo sapiens
4 PLXNA2 5362
Affinity Capture-MS Homo sapiens
5 NOTCH2NL 388677
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 PPOX 5498
Affinity Capture-MS Homo sapiens
7 PCBP3 54039
Affinity Capture-MS Homo sapiens
8 NPC2 10577
Affinity Capture-MS Homo sapiens
9 HSPA5 3309
Affinity Capture-MS Homo sapiens
10 TUBB 203068
Affinity Capture-MS Homo sapiens
11 C10orf53  
Affinity Capture-MS Homo sapiens
12 QSOX1 5768
Affinity Capture-MS Homo sapiens
13 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
14 POMGNT2  
Affinity Capture-MS Homo sapiens
15 PTCD2  
Affinity Capture-MS Homo sapiens
16 IDUA 3425
Affinity Capture-MS Homo sapiens
17 PRF1  
Affinity Capture-MS Homo sapiens
18 ADAMTS7  
Affinity Capture-MS Homo sapiens
19 DDX19B 11269
Affinity Capture-MS Homo sapiens
20 RTCA 8634
Affinity Capture-MS Homo sapiens
21 FBXO21  
Affinity Capture-MS Homo sapiens
22 FAM132B  
Affinity Capture-MS Homo sapiens
23 BCKDHA 593
Affinity Capture-MS Homo sapiens
24 TUBB8 347688
Affinity Capture-MS Homo sapiens
25 TIMM10  
Affinity Capture-MS Homo sapiens
26 LOXL2 4017
Affinity Capture-MS Homo sapiens
27 OLFM2  
Affinity Capture-MS Homo sapiens
28 CDK5RAP1  
Affinity Capture-MS Homo sapiens
29 SETX  
Affinity Capture-MS Homo sapiens
30 FOXRED2  
Affinity Capture-MS Homo sapiens
31 AAAS 8086
Affinity Capture-MS Homo sapiens
32 GAS6 2621
Affinity Capture-MS Homo sapiens
33 CORO1C 23603
Affinity Capture-MS Homo sapiens
34 EDEM3 80267
Affinity Capture-MS Homo sapiens
35 FBXL12 54850
Affinity Capture-MS Homo sapiens
36 TUBA1A 7846
Affinity Capture-MS Homo sapiens
37 HBQ1  
Affinity Capture-MS Homo sapiens
38 LPCAT2 54947
Affinity Capture-MS Homo sapiens
39 DCAF6 55827
Affinity Capture-MS Homo sapiens
40 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 L2HGDH  
Affinity Capture-MS Homo sapiens
42 GALNT18  
Affinity Capture-MS Homo sapiens
43 IMMP1L  
Affinity Capture-MS Homo sapiens
44 C9orf41  
Affinity Capture-MS Homo sapiens
45 PLAU 5328
Affinity Capture-MS Homo sapiens
46 LPCAT4  
Affinity Capture-MS Homo sapiens
47 CD151 977
Affinity Capture-MS Homo sapiens
48 METRNL 284207
Affinity Capture-MS Homo sapiens
49 MYO9B 4650
Affinity Capture-MS Homo sapiens
50 LAMA5 3911
Affinity Capture-MS Homo sapiens
51 POLDIP2 26073
Affinity Capture-MS Homo sapiens
52 STK11 6794
Affinity Capture-MS Homo sapiens
53 KRT40  
Two-hybrid Homo sapiens
54 P3H3 10536
Affinity Capture-MS Homo sapiens
55 PCSK9 255738
Affinity Capture-MS Homo sapiens
56 SLC27A1 376497
Affinity Capture-MS Homo sapiens
57 GANAB 23193
Affinity Capture-MS Homo sapiens
58 PLXNA3 55558
Affinity Capture-MS Homo sapiens
59 BMP1 649
Affinity Capture-MS Homo sapiens
60 TRMT2A 27037
Affinity Capture-MS Homo sapiens
61 KRT31 3881
Two-hybrid Homo sapiens
62 RAD51C  
Affinity Capture-MS Homo sapiens
63 WNT16  
Affinity Capture-MS Homo sapiens
64 PLXNA1 5361
Affinity Capture-MS Homo sapiens
65 RTEL1 51750
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CA6 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Reversible hydration of carbon dioxide TAS Reactome





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