Gene description for RTCA
Gene name RNA 3'-terminal phosphate cyclase
Gene symbol RTCA
Other names/aliases RPC
RTC1
RTCD1
Species Homo sapiens
 Database cross references - RTCA
ExoCarta ExoCarta_8634
Entrez Gene 8634
HGNC 17981
MIM 611286
UniProt O00442  
 RTCA identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for RTCA
Molecular Function
    ATP binding GO:0005524 IEA
    poly(A) RNA binding GO:0044822 IDA
    RNA-3'-phosphate cyclase activity GO:0003963 IEA
    RNA binding GO:0003723 TAS
Biological Process
    RNA processing GO:0006396 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified RTCA in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RTCA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCKDK  
Affinity Capture-MS Homo sapiens
2 RPL23A 6147
Affinity Capture-MS Homo sapiens
3 FBL 2091
Affinity Capture-MS Homo sapiens
4 RPL18A 6142
Affinity Capture-MS Homo sapiens
5 DDX21 9188
Affinity Capture-MS Homo sapiens
6 RPL21 6144
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RTCA is involved
No pathways found





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