Gene description for CRNN
Gene name cornulin
Gene symbol CRNN
Other names/aliases C1orf10
DRC1
PDRC1
SEP53
Species Homo sapiens
 Database cross references - CRNN
ExoCarta ExoCarta_49860
Vesiclepedia VP_49860
Entrez Gene 49860
HGNC 1230
MIM 611312
UniProt Q9UBG3  
 CRNN identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for CRNN
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 NAS
    protein binding GO:0005515 IPI
    transition metal ion binding GO:0046914 IEA
    calcium-dependent protein binding GO:0048306 IBA
Biological Process
    response to heat GO:0009408 IDA
    regulation of gene expression GO:0010468 IMP
    positive regulation of keratinocyte proliferation GO:0010838 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IBA
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IMP
    cellular response to cytokine stimulus GO:0071345 IDA
    cell-cell adhesion GO:0098609 IDA
    positive regulation of cell cycle G1/S phase transition GO:1902808 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 TAS
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CRNN in exosomes
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CRNN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Affinity Capture-MS Homo sapiens
2 PA2G4 5036
Affinity Capture-MS Homo sapiens
3 ZNF550  
Affinity Capture-MS Homo sapiens
4 NUP54 53371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 UBE2N 7334
Affinity Capture-MS Homo sapiens
6 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
7 SNX15  
Affinity Capture-MS Homo sapiens
8 RAG2  
Affinity Capture-MS Homo sapiens
9 TMEM141  
Affinity Capture-MS Homo sapiens
10 SLMAP 7871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 LMO4  
Two-hybrid Homo sapiens
12 GAS2L1 10634
Affinity Capture-MS Homo sapiens
13 OMP  
Affinity Capture-MS Homo sapiens
14 GPI 2821
Affinity Capture-MS Homo sapiens
15 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 WWOX 51741
Affinity Capture-MS Homo sapiens
17 PIFO  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RTCA 8634
Affinity Capture-MS Homo sapiens
19 SFTA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TRIM66  
Affinity Capture-MS Homo sapiens
21 NSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ZNF154  
Affinity Capture-MS Homo sapiens
23 UCP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ERCC3  
Affinity Capture-MS Homo sapiens
25 PDIA3 2923
Affinity Capture-MS Homo sapiens
26 EBF2  
Affinity Capture-MS Homo sapiens
27 NRM 11270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FNBP4  
Affinity Capture-MS Homo sapiens
29 DCTN5 84516
Affinity Capture-MS Homo sapiens
30 NOP10 55505
Affinity Capture-MS Homo sapiens
31 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 DNAH17 8632
Affinity Capture-MS Homo sapiens
33 FNDC5  
Affinity Capture-MS Homo sapiens
34 HSF2  
Affinity Capture-MS Homo sapiens
35 SRRT 51593
Affinity Capture-MS Homo sapiens
36 KIR2DS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 C1orf162  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PBX4  
Affinity Capture-MS Homo sapiens
39 IDH2 3418
Affinity Capture-MS Homo sapiens
40 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SCAMP2 10066
Affinity Capture-MS Homo sapiens
42 ANXA5 308
Affinity Capture-MS Homo sapiens
43 EIF5B 9669
Affinity Capture-MS Homo sapiens
44 DDX54 79039
Affinity Capture-MS Homo sapiens
45 WDR59 79726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 STK11 6794
Affinity Capture-MS Homo sapiens
47 GTF2A2 2958
Affinity Capture-MS Homo sapiens
48 ZBTB1  
Affinity Capture-MS Homo sapiens
49 SNW1 22938
Affinity Capture-MS Homo sapiens
50 RCAN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 UTP11L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TIMM10  
Affinity Capture-MS Homo sapiens
53 WHSC1L1  
Affinity Capture-MS Homo sapiens
54 TNFRSF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 OR13C3  
Affinity Capture-MS Homo sapiens
56 NPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 COMMD1 150684
Affinity Capture-MS Homo sapiens
58 FAM213A 84293
Affinity Capture-MS Homo sapiens
59 SND1 27044
Affinity Capture-MS Homo sapiens
60 CORO1C 23603
Affinity Capture-MS Homo sapiens
61 STIP1 10963
Affinity Capture-MS Homo sapiens
62 TMEM231 79583
Affinity Capture-MS Homo sapiens
63 CDK11A 728642
Affinity Capture-MS Homo sapiens
64 TRAP1 10131
Affinity Capture-MS Homo sapiens
65 B3GNT5  
Affinity Capture-MS Homo sapiens
66 NKAP 79576
Affinity Capture-MS Homo sapiens
67 LY86  
Affinity Capture-MS Homo sapiens
68 SSX2IP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CRNN is involved
No pathways found





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