Gene description for COMMD1
Gene name copper metabolism (Murr1) domain containing 1
Gene symbol COMMD1
Other names/aliases C2orf5
MURR1
Species Homo sapiens
 Database cross references - COMMD1
ExoCarta ExoCarta_150684
Vesiclepedia VP_150684
Entrez Gene 150684
HGNC 23024
MIM 607238
UniProt Q8N668  
 COMMD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COMMD1
Molecular Function
    copper ion binding GO:0005507 IDA
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
    sodium channel inhibitor activity GO:0019871 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
    phosphatidic acid binding GO:0070300 IDA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
Biological Process
    nucleotide-excision repair GO:0006289 IMP
    Golgi to plasma membrane transport GO:0006893 IMP
    protein transport GO:0015031 IEA
    positive regulation of protein ubiquitination GO:0031398 IBA
    positive regulation of protein ubiquitination GO:0031398 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IBA
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IMP
    plasma membrane to endosome transport GO:0048227 IDA
    copper ion homeostasis GO:0055070 IBA
    copper ion homeostasis GO:0055070 IDA
    negative regulation of sodium ion transmembrane transport GO:1902306 IBA
    negative regulation of sodium ion transmembrane transport GO:1902306 IDA
    negative regulation of sodium ion transmembrane transport GO:1902306 IMP
    negative regulation of protein localization to cell surface GO:2000009 IBA
    negative regulation of protein localization to cell surface GO:2000009 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    endosome GO:0005768 IBA
    early endosome GO:0005769 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    endosome membrane GO:0010008 IEA
    Cul2-RING ubiquitin ligase complex GO:0031462 IDA
    recycling endosome GO:0055037 IDA
 Experiment description of studies that identified COMMD1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COMMD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCAR1 55749
Affinity Capture-MS Homo sapiens
2 LIG4 3981
Two-hybrid Homo sapiens
3 XIAP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 TCEB1 6921
Reconstituted Complex Homo sapiens
5 FAM167A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TBC1D4  
Affinity Capture-MS Homo sapiens
7 REL 5966
Affinity Capture-Western Homo sapiens
8 NUP62 23636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 NFYC 4802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SUB1 10923
Affinity Capture-MS Homo sapiens
11 BRCA1 672
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
12 DSCR3 10311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NMRAL1 57407
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 VHL  
Two-hybrid Homo sapiens
15 VPS29 51699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 NFKB1 4790
Affinity Capture-Western Homo sapiens
17 C16orf62 57020
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LYZ 4069
Affinity Capture-MS Homo sapiens
19 COMMD9 29099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 E2F6 1876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 STK11IP 114790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RSRC1  
Affinity Capture-MS Homo sapiens
23 BIRC3 330
Affinity Capture-Western Homo sapiens
24 COMMD10 51397
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TRIM16L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CST1  
Affinity Capture-MS Homo sapiens
27 CUL1 8454
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
28 TMEM132D  
Two-hybrid Homo sapiens
29 OR13G1  
Affinity Capture-MS Homo sapiens
30 COMMD4 54939
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SOD1 6647
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
32 CCDC114  
Affinity Capture-MS Homo sapiens
33 C15orf59  
Affinity Capture-MS Homo sapiens
34 CST2  
Affinity Capture-MS Homo sapiens
35 TFDP2  
Affinity Capture-MS Homo sapiens
36 COMMD7 149951
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 IGHA2 3494
Affinity Capture-MS Homo sapiens
38 CUL4B 8450
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
39 PARK2  
Reconstituted Complex Homo sapiens
40 CLU 1191
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 ATP7B 540
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 SRSF6 6431
Affinity Capture-MS Homo sapiens
43 TFDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 BARD1 580
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
45 SNAP29 9342
Affinity Capture-MS Homo sapiens
46 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CUL2 8453
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
48 TRIM72  
Affinity Capture-MS Homo sapiens
49 NFKB2 4791
Affinity Capture-Western Homo sapiens
50 COMMD3 23412
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RAD21 5885
Affinity Capture-MS Homo sapiens
52 CRNN 49860
Affinity Capture-MS Homo sapiens
53 HMGB2 3148
Two-hybrid Homo sapiens
54 VCP 7415
Affinity Capture-MS Homo sapiens
55 SCNN1G  
Affinity Capture-Western Homo sapiens
56 CNGA4  
Affinity Capture-MS Homo sapiens
57 FAM45A 404636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 Ranbp1 19385
Affinity Capture-MS Mus musculus
59 COMMD2 51122
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 STMN2  
Affinity Capture-MS Homo sapiens
61 IGHA1 3493
Affinity Capture-MS Homo sapiens
62 C6orf58  
Affinity Capture-MS Homo sapiens
63 DHX15 1665
Affinity Capture-MS Homo sapiens
64 COMMD8 54951
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 NFKBIA  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 SOCS1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
67 CUL3 8452
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
68 U2SURP 23350
Affinity Capture-MS Homo sapiens
69 ATAD3C 219293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 TTF2 8458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CNKSR3 154043
Affinity Capture-MS Homo sapiens
72 NAIP  
Affinity Capture-Western Homo sapiens
73 TCEAL8  
Two-hybrid Homo sapiens
74 G6PD 2539
Affinity Capture-MS Homo sapiens
75 AMY1C 278
Affinity Capture-MS Homo sapiens
76 CST4 1472
Affinity Capture-MS Homo sapiens
77 COMMD6 170622
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 HSPA4 3308
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
79 BAHCC1  
Two-hybrid Homo sapiens
80 SCNN1D  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
81 ARGLU1  
Affinity Capture-MS Homo sapiens
82 AKT1 207
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
83 ATP7A 538
Affinity Capture-Western Homo sapiens
84 KIF2B 84643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 RBM17 84991
Affinity Capture-MS Homo sapiens
86 PIGR 5284
Affinity Capture-MS Homo sapiens
87 COMMD1 150684
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
88 HIF1A 3091
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
89 SUPT16H 11198
Affinity Capture-MS Homo sapiens
90 RELA 5970
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
91 SGK1  
Affinity Capture-Western Homo sapiens
92 KAT2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
93 SPP1 6696
Two-hybrid Homo sapiens
94 COMMD5 28991
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 CUL5 8065
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
96 CWF19L2  
Affinity Capture-MS Homo sapiens
97 SCNN1B 6338
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
98 CCDC93 54520
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 COMMD3-BMI1 100532731
Affinity Capture-MS Homo sapiens
100 ZG16B 124220
Affinity Capture-MS Homo sapiens
101 RELB  
Affinity Capture-Western Homo sapiens
102 GRSF1 2926
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
103 CDKN2A 1029
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
104 CUL7 9820
Reconstituted Complex Homo sapiens
105 CFTR 1080
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
106 SSRP1 6749
Affinity Capture-MS Homo sapiens
107 VPS33B 26276
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 CUL4A 8451
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
109 EP300 2033
Affinity Capture-Western Homo sapiens
110 BCR 613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which COMMD1 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here