Gene description for ATP7B
Gene name ATPase, Cu++ transporting, beta polypeptide
Gene symbol ATP7B
Other names/aliases PWD
WC1
WD
WND
Species Homo sapiens
 Database cross references - ATP7B
ExoCarta ExoCarta_540
Entrez Gene 540
HGNC 870
MIM 606882
UniProt P35670  
 ATP7B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ATP7B
Molecular Function
    ATP binding GO:0005524 IDA
    protein binding GO:0005515 IPI
    copper ion binding GO:0005507 IDA
    copper-exporting ATPase activity GO:0004008 TAS
Biological Process
    copper ion import GO:0015677 IDA
    intracellular copper ion transport GO:0015680 IEA
    metabolic process GO:0008152 IEA
    copper ion transport GO:0006825 IGI
    transmembrane transport GO:0055085 TAS
    lactation GO:0007595 IEA
    cellular zinc ion homeostasis GO:0006882 IEA
    copper ion export GO:0060003 IEA
    cellular copper ion homeostasis GO:0006878 TAS
    sequestering of calcium ion GO:0051208 IDA
    ion transmembrane transport GO:0034220 TAS
    response to copper ion GO:0046688 IDA
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    Golgi membrane GO:0000139 TAS
    mitochondrion GO:0005739 IEA
    membrane GO:0016020 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
    integral component of plasma membrane GO:0005887 TAS
    trans-Golgi network GO:0005802 IDA
    late endosome GO:0005770 IDA
    basolateral plasma membrane GO:0016323 IDA
 Experiment description of studies that identified ATP7B in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP7B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATOX1  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 GLRX 2745
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ATP7B is involved
PathwayEvidenceSource
Ion transport by P-type ATPases TAS Reactome





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