Gene description for GLRX
Gene name glutaredoxin (thioltransferase)
Gene symbol GLRX
Other names/aliases GRX
GRX1
Species Homo sapiens
 Database cross references - GLRX
ExoCarta ExoCarta_2745
Entrez Gene 2745
HGNC 4330
MIM 600443
UniProt P35754  
 GLRX identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Thymus 23844026    
 Gene ontology annotations for GLRX
Molecular Function
    protein N-terminus binding GO:0047485 IPI
    glutathione oxidoreductase activity GO:0097573 TAS
    glutathione disulfide oxidoreductase activity GO:0015038 TAS
    electron carrier activity GO:0009055 IEA
Biological Process
    positive regulation of sodium ion transmembrane transporter activity GO:2000651 IDA
    small molecule metabolic process GO:0044281 TAS
    nucleobase-containing small molecule interconversion GO:0015949 TAS
    positive regulation of membrane potential GO:0045838 IDA
    oxidation-reduction process GO:0055114 IEA
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    cell redox homeostasis GO:0045454 IEA
    protein deglutathionylation GO:0080058 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
    mitochondrion GO:0005739 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified GLRX in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GLRX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP7B 540
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 MAP3K5  
Invitro Homo sapiens
3 ATP7A 538
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which GLRX is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates TAS Reactome





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