Gene description for SCNN1B
Gene name sodium channel, non voltage gated 1 beta subunit
Gene symbol SCNN1B
Other names/aliases BESC1
ENaCb
ENaCbeta
SCNEB
Species Homo sapiens
 Database cross references - SCNN1B
ExoCarta ExoCarta_6338
Vesiclepedia VP_6338
Entrez Gene 6338
HGNC 10600
MIM 600760
UniProt P51168  
 SCNN1B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SCNN1B
Molecular Function
    WW domain binding GO:0050699 IPI
    ligand-gated sodium channel activity GO:0015280 IDA
    protein binding GO:0005515 IPI
Biological Process
    ion transmembrane transport GO:0034220 TAS
    sensory perception of taste GO:0050909 IEA
    multicellular organismal water homeostasis GO:0050891 IDA
    response to stimulus GO:0050896 IEA
    transmembrane transport GO:0055085 TAS
    sodium ion homeostasis GO:0055078 IDA
    sodium ion transport GO:0006814 TAS
    sodium ion transmembrane transport GO:0035725 IDA
    excretion GO:0007588 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 IDA
    plasma membrane GO:0005886 TAS
    cytoplasmic vesicle membrane GO:0030659 IEA
    extracellular exosome GO:0070062 IDA
    sodium channel complex GO:0034706 IDA
    external side of plasma membrane GO:0009897 IEA
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified SCNN1B in exosomes
1
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SCNN1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SCNN1B is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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