Gene description for SERP1
Gene name stress-associated endoplasmic reticulum protein 1
Gene symbol SERP1
Other names/aliases RAMP4
Species Homo sapiens
 Database cross references - SERP1
ExoCarta ExoCarta_27230
Entrez Gene 27230
HGNC 10759
UniProt Q9Y6X1  
 SERP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for SERP1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    positive regulation of insulin secretion GO:0032024 IEA
    muscle organ morphogenesis GO:0048644 IEA
    IRE1-mediated unfolded protein response GO:0036498 TAS
    protein glycosylation GO:0006486 IEA
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    response to stress GO:0006950 TAS
    positive regulation of growth hormone secretion GO:0060124 IEA
    protein transport GO:0015031 IEA
    positive regulation of translation GO:0045727 IEA
    post-embryonic development GO:0009791 IEA
    plasma membrane organization GO:0007009 TAS
    positive regulation of organ growth GO:0046622 IEA
    skeletal system development GO:0001501 IEA
    glucose metabolic process GO:0006006 IEA
    cellular protein modification process GO:0006464 TAS
    multicellular organismal aging GO:0010259 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum GO:0005783 TAS
    cytoplasmic microtubule GO:0005881 IDA
    cytosol GO:0005829 TAS
    ribosome GO:0005840 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified SERP1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SERP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERP1 is involved
PathwayEvidenceSource
XBP1(S) activates chaperone genes TAS Reactome





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