Gene description for SERP1
Gene name stress-associated endoplasmic reticulum protein 1
Gene symbol SERP1
Other names/aliases RAMP4
Species Homo sapiens
 Database cross references - SERP1
ExoCarta ExoCarta_27230
Vesiclepedia VP_27230
Entrez Gene 27230
HGNC 10759
UniProt Q9Y6X1  
 SERP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for SERP1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    skeletal system development GO:0001501 IEA
    glucose metabolic process GO:0006006 IEA
    protein glycosylation GO:0006486 TAS
    plasma membrane organization GO:0007009 TAS
    post-embryonic development GO:0009791 IEA
    insulin secretion GO:0030073 IEA
    endoplasmic reticulum unfolded protein response GO:0030968 IBA
    positive regulation of insulin secretion GO:0032024 IEA
    protein modification process GO:0036211 TAS
    positive regulation of translation GO:0045727 IEA
    positive regulation of organ growth GO:0046622 IEA
    muscle organ morphogenesis GO:0048644 IEA
    positive regulation of growth hormone secretion GO:0060124 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 TAS
    ribosome GO:0005840 TAS
    cytoplasmic microtubule GO:0005881 IDA
 Experiment description of studies that identified SERP1 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SERP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC11C 90701
Two-hybrid Homo sapiens
2 TMEM52B 120939
Two-hybrid Homo sapiens
3 SCNN1G  
PCA Homo sapiens
4 BSCL2  
Two-hybrid Homo sapiens
5 LPPR1  
Two-hybrid Homo sapiens
6 GPX8 493869
Two-hybrid Homo sapiens
7 SLC10A6  
Two-hybrid Homo sapiens
8 JAGN1 84522
Two-hybrid Homo sapiens
9 SSMEM1  
Two-hybrid Homo sapiens
10 SCNN1A  
PCA Homo sapiens
11 KCNF1  
Two-hybrid Homo sapiens
12 GJB3  
Two-hybrid Homo sapiens
13 FRMD3  
Two-hybrid Homo sapiens
14 MTIF3  
Two-hybrid Homo sapiens
15 CRB3 92359
Two-hybrid Homo sapiens
16 TMEM14B  
Two-hybrid Homo sapiens
17 REEP4  
Two-hybrid Homo sapiens
18 EBP  
Two-hybrid Homo sapiens
19 CD79A  
Two-hybrid Homo sapiens
20 FAM174A 345757
Two-hybrid Homo sapiens
21 STX4 6810
Two-hybrid Homo sapiens
22 DDX58 23586
Affinity Capture-RNA Homo sapiens
23 IL3RA  
Two-hybrid Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 KIR3DL3  
Two-hybrid Homo sapiens
26 FAM209A 200232
Two-hybrid Homo sapiens
27 SERP2  
Cross-Linking-MS (XL-MS) Homo sapiens
28 ALG10  
Cross-Linking-MS (XL-MS) Homo sapiens
29 ALG3 10195
Two-hybrid Homo sapiens
30 HSD17B13  
Two-hybrid Homo sapiens
31 STX1A 6804
Two-hybrid Homo sapiens
32 TMEM79  
Two-hybrid Homo sapiens
33 GPR37L1  
Two-hybrid Homo sapiens
34 GKN1  
Two-hybrid Homo sapiens
35 VKORC1 79001
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
36 AQP8  
Two-hybrid Homo sapiens
37 APH1A 51107
Two-hybrid Homo sapiens
38 TMEM56  
Two-hybrid Homo sapiens
39 SCNN1B 6338
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 SGTA 6449
Affinity Capture-Western Homo sapiens
41 LHFPL5  
Two-hybrid Homo sapiens
42 GJB5  
Two-hybrid Homo sapiens
43 ZNF609  
Cross-Linking-MS (XL-MS) Homo sapiens
44 HIATL1 84641
Two-hybrid Homo sapiens
45 FAM210B  
Two-hybrid Homo sapiens
46 STX2 2054
Two-hybrid Homo sapiens
View the network image/svg+xml



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