Gene description for HIATL1
Gene name hippocampus abundant transcript-like 1
Gene symbol HIATL1
Other names/aliases -
Species Homo sapiens
 Database cross references - HIATL1
ExoCarta ExoCarta_84641
Vesiclepedia VP_84641
Entrez Gene 84641
HGNC 23376
UniProt Q5SR56  
 HIATL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for HIATL1
Molecular Function
    protein binding GO:0005515 IPI
    transmembrane transporter activity GO:0022857 IEA
Biological Process
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified HIATL1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for HIATL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM119 338773
Two-hybrid Homo sapiens
2 EMC6 83460
Two-hybrid Homo sapiens
3 TMEM239  
Two-hybrid Homo sapiens
4 SMAGP  
Two-hybrid Homo sapiens
5 UNC50  
Two-hybrid Homo sapiens
6 PKMYT1  
Two-hybrid Homo sapiens
7 RNF24  
Two-hybrid Homo sapiens
8 CSGALNACT2 55454
Two-hybrid Homo sapiens
9 PEX16 9409
Two-hybrid Homo sapiens
10 CYB5B 80777
Two-hybrid Homo sapiens
11 TMBIM6 7009
Two-hybrid Homo sapiens
12 LEPROTL1 23484
Two-hybrid Homo sapiens
13 SACM1L 22908
Two-hybrid Homo sapiens
14 C14orf1 11161
Two-hybrid Homo sapiens
15 PQLC1  
Two-hybrid Homo sapiens
16 ZFPL1 7542
Two-hybrid Homo sapiens
17 YIPF6 286451
Two-hybrid Homo sapiens
18 ZDHHC24  
Two-hybrid Homo sapiens
19 UNK  
Affinity Capture-RNA Homo sapiens
20 THSD7B  
Two-hybrid Homo sapiens
21 CCL4L2  
Two-hybrid Homo sapiens
22 TREX1  
Two-hybrid Homo sapiens
23 TMEM19  
Two-hybrid Homo sapiens
24 MS4A1 931
Two-hybrid Homo sapiens
25 CMTM3 123920
Two-hybrid Homo sapiens
26 YIPF2 78992
Two-hybrid Homo sapiens
27 FKBP8 23770
Two-hybrid Homo sapiens
28 GOSR2 9570
Two-hybrid Homo sapiens
29 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
30 ARL6IP1 23204
Two-hybrid Homo sapiens
31 FUNDC2 65991
Two-hybrid Homo sapiens
32 LAT 27040
Two-hybrid Homo sapiens
33 PRRT2  
Two-hybrid Homo sapiens
34 LRP10 26020
Two-hybrid Homo sapiens
35 TMEM208  
Two-hybrid Homo sapiens
36 ORMDL1 94101
Two-hybrid Homo sapiens
37 GIMAP1  
Two-hybrid Homo sapiens
38 SERP2  
Two-hybrid Homo sapiens
39 TIMMDC1  
Two-hybrid Homo sapiens
40 TSNARE1  
Two-hybrid Homo sapiens
41 TMEM229B  
Two-hybrid Homo sapiens
42 TUSC5  
Two-hybrid Homo sapiens
43 TPRG1  
Two-hybrid Homo sapiens
44 STX3 6809
Two-hybrid Homo sapiens
45 AGPAT3 56894
Two-hybrid Homo sapiens
46 ADIPOQ 9370
Two-hybrid Homo sapiens
47 GRM2 2912
Two-hybrid Homo sapiens
48 YIPF4 84272
Two-hybrid Homo sapiens
49 C4orf3  
Two-hybrid Homo sapiens
50 TMEM31  
Two-hybrid Homo sapiens
51 CFHR5  
Two-hybrid Homo sapiens
52 KTN1 3895
Two-hybrid Homo sapiens
53 NAT8  
Two-hybrid Homo sapiens
54 C14orf180  
Two-hybrid Homo sapiens
55 CLDN4 1364
Two-hybrid Homo sapiens
56 UBE2J1 51465
Two-hybrid Homo sapiens
57 DNAJC30  
Two-hybrid Homo sapiens
58 SERP1 27230
Two-hybrid Homo sapiens
59 C17orf62 79415
Two-hybrid Homo sapiens
60 ATP13A1 57130
Two-hybrid Homo sapiens
61 TMX2 51075
Two-hybrid Homo sapiens
62 BNIP3 664
Two-hybrid Homo sapiens
63 SLC25A46 91137
Two-hybrid Homo sapiens
64 TMEM167B  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HIATL1 is involved
No pathways found





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