Gene description for YIPF4
Gene name Yip1 domain family, member 4
Gene symbol YIPF4
Other names/aliases FinGER4
Nbla11189
Species Homo sapiens
 Database cross references - YIPF4
ExoCarta ExoCarta_84272
Vesiclepedia VP_84272
Entrez Gene 84272
HGNC 28145
UniProt Q9BSR8  
 YIPF4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for YIPF4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    vesicle fusion with Golgi apparatus GO:0048280 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IBA
    plasma membrane GO:0005886 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified YIPF4 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for YIPF4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTGIR  
Affinity Capture-MS Homo sapiens
2 SLC30A8  
Two-hybrid Homo sapiens
3 SLC17A2  
Affinity Capture-MS Homo sapiens
4 SLC35A4  
Two-hybrid Homo sapiens
5 VIPR2  
Affinity Capture-MS Homo sapiens
6 ATP13A3 79572
Affinity Capture-MS Homo sapiens
7 NAT8  
Two-hybrid Homo sapiens
8 TMEM63B 55362
Affinity Capture-MS Homo sapiens
9 UNK  
Affinity Capture-RNA Homo sapiens
10 IER3IP1 51124
Two-hybrid Homo sapiens
11 FCER1G 2207
Two-hybrid Homo sapiens
12 ERGIC3 51614
Two-hybrid Homo sapiens
13 TMEM14B  
Two-hybrid Homo sapiens
14 CHRM4  
Affinity Capture-MS Homo sapiens
15 REEP4  
Two-hybrid Homo sapiens
16 EBP  
Two-hybrid Homo sapiens
17 CD79A  
Two-hybrid Homo sapiens
18 ARL6IP1 23204
Two-hybrid Homo sapiens
19 FSHR  
Affinity Capture-MS Homo sapiens
20 SLC22A9  
Affinity Capture-MS Homo sapiens
21 RNF5  
Two-hybrid Homo sapiens
22 CHRM3 1131
Affinity Capture-MS Homo sapiens
23 GPR152  
Two-hybrid Homo sapiens
24 GPR52  
Affinity Capture-MS Homo sapiens
25 GPR42  
Two-hybrid Homo sapiens
26 TSNARE1  
Two-hybrid Homo sapiens
27 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 HSD17B13  
Two-hybrid Homo sapiens
29 CNR2  
Two-hybrid Homo sapiens
30 YIF1A 10897
Two-hybrid Homo sapiens
31 SPPL2B 56928
Affinity Capture-MS Homo sapiens
32 SLC10A1  
Two-hybrid Homo sapiens
33 IPPK  
Affinity Capture-MS Homo sapiens
34 TVP23B  
Two-hybrid Homo sapiens
35 PTGFR 5737
Affinity Capture-MS Homo sapiens
36 TMEM63A 9725
Affinity Capture-MS Homo sapiens
37 YIPF3 25844
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
38 AP3B1 8546
Co-fractionation Homo sapiens
39 RNF185  
Two-hybrid Homo sapiens
40 FATE1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 Yipf4  
Affinity Capture-MS Mus musculus
42 HIATL1 84641
Two-hybrid Homo sapiens
43 SCN3B  
Two-hybrid Homo sapiens
44 ZDHHC15 158866
Two-hybrid Homo sapiens
45 TMEM56  
Two-hybrid Homo sapiens
46 KCNA5  
Affinity Capture-MS Homo sapiens
47 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which YIPF4 is involved
No pathways found





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