Gene description for ZDHHC15
Gene name zinc finger, DHHC-type containing 15
Gene symbol ZDHHC15
Other names/aliases MRX91
Species Homo sapiens
 Database cross references - ZDHHC15
ExoCarta ExoCarta_158866
Vesiclepedia VP_158866
Entrez Gene 158866
HGNC 20342
MIM 300576
UniProt Q96MV8  
 ZDHHC15 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ZDHHC15
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 ISS
    palmitoyltransferase activity GO:0016409 IDA
    protein-cysteine S-myristoyltransferase activity GO:0019705 IEA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IBA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IDA
    protein-cysteine S-stearoyltransferase activity GO:0140439 IEA
Biological Process
    protein targeting to membrane GO:0006612 IBA
    synaptic vesicle maturation GO:0016188 IBA
    peptidyl-L-cysteine S-palmitoylation GO:0018230 IDA
    protein palmitoylation GO:0018345 IDA
    regulation of dendritic spine morphogenesis GO:0061001 ISS
    protein localization to postsynapse GO:0062237 ISS
    protein localization to membrane GO:0072657 IMP
    protein targeting to Golgi apparatus GO:0140450 IMP
    positive regulation of dendrite development GO:1900006 ISS
Subcellular Localization
    Golgi membrane GO:0000139 ISS
    endoplasmic reticulum GO:0005783 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    postsynaptic density GO:0014069 IEA
    postsynapse GO:0098794 ISS
 Experiment description of studies that identified ZDHHC15 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ZDHHC15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM52B 120939
Two-hybrid Homo sapiens
2 TMEM14C 51522
Two-hybrid Homo sapiens
3 PEX16 9409
Two-hybrid Homo sapiens
4 SLC10A6  
Two-hybrid Homo sapiens
5 ORMDL1 94101
Two-hybrid Homo sapiens
6 VAPB 9217
Two-hybrid Homo sapiens
7 LEPROTL1 23484
Two-hybrid Homo sapiens
8 MTIF3  
Two-hybrid Homo sapiens
9 MCEMP1  
Two-hybrid Homo sapiens
10 SMIM1 388588
Two-hybrid Homo sapiens
11 CLRN1  
Two-hybrid Homo sapiens
12 TMEM120B  
Two-hybrid Homo sapiens
13 ERGIC3 51614
Two-hybrid Homo sapiens
14 TMEM128  
Two-hybrid Homo sapiens
15 DHRSX 207063
Two-hybrid Homo sapiens
16 TMEM42  
Two-hybrid Homo sapiens
17 CD79A  
Two-hybrid Homo sapiens
18 GOLGA7B  
Two-hybrid Homo sapiens
19 CREB3L1  
Two-hybrid Homo sapiens
20 PLLP  
Two-hybrid Homo sapiens
21 CLEC10A  
Two-hybrid Homo sapiens
22 TUFM 7284
Two-hybrid Homo sapiens
23 LSMEM1  
Two-hybrid Homo sapiens
24 GPR152  
Two-hybrid Homo sapiens
25 TNFRSF10B 8795
Two-hybrid Homo sapiens
26 TSNARE1  
Two-hybrid Homo sapiens
27 C16orf58 64755
Two-hybrid Homo sapiens
28 STX3 6809
Two-hybrid Homo sapiens
29 LEMD1  
Two-hybrid Homo sapiens
30 TMEM222 84065
Two-hybrid Homo sapiens
31 YIPF4 84272
Two-hybrid Homo sapiens
32 GIMAP1  
Two-hybrid Homo sapiens
33 C2orf82  
Two-hybrid Homo sapiens
34 CERCAM 51148
Two-hybrid Homo sapiens
35 CELA2B  
Two-hybrid Homo sapiens
36 BNIP3 664
Two-hybrid Homo sapiens
37 FBXW8 26259
Affinity Capture-MS Homo sapiens
38 C14orf180  
Two-hybrid Homo sapiens
39 ARL13B 200894
Two-hybrid Homo sapiens
40 C10orf35  
Two-hybrid Homo sapiens
41 LHFPL5  
Two-hybrid Homo sapiens
42 PRAF2 11230
Two-hybrid Homo sapiens
43 TMEFF2  
Two-hybrid Homo sapiens
44 ORMDL2 29095
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZDHHC15 is involved
No pathways found





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