Gene description for TMEM222
Gene name transmembrane protein 222
Gene symbol TMEM222
Other names/aliases C1orf160
Species Homo sapiens
 Database cross references - TMEM222
ExoCarta ExoCarta_84065
Vesiclepedia VP_84065
Entrez Gene 84065
HGNC 25363
UniProt Q9H0R3  
 TMEM222 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM222
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    membrane GO:0016020 IEA
    dendrite GO:0030425 IDA
 Experiment description of studies that identified TMEM222 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM222
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM35  
Two-hybrid Homo sapiens
2 ABHD16A 7920
Two-hybrid Homo sapiens
3 BSCL2  
Two-hybrid Homo sapiens
4 KIR2DL3  
Two-hybrid Homo sapiens
5 RNASEK  
Two-hybrid Homo sapiens
6 SSMEM1  
Two-hybrid Homo sapiens
7 C14orf1 11161
Two-hybrid Homo sapiens
8 LAMP3  
Proximity Label-MS Homo sapiens
9 LRRC59 55379
Two-hybrid Homo sapiens
10 NCR3LG1 374383
Two-hybrid Homo sapiens
11 CRB3 92359
Two-hybrid Homo sapiens
12 CLRN1  
Two-hybrid Homo sapiens
13 CLDN5 7122
Two-hybrid Homo sapiens
14 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ERGIC3 51614
Two-hybrid Homo sapiens
16 TMEM14B  
Two-hybrid Homo sapiens
17 PEX12  
Two-hybrid Homo sapiens
18 ARF6 382
Proximity Label-MS Homo sapiens
19 SLC10A2  
Two-hybrid Homo sapiens
20 CD79A  
Two-hybrid Homo sapiens
21 RTN4 57142
Affinity Capture-MS Homo sapiens
22 CREB3L1  
Two-hybrid Homo sapiens
23 NXF1 10482
Affinity Capture-RNA Homo sapiens
24 FAM209A 200232
Two-hybrid Homo sapiens
25 PTGES 9536
Two-hybrid Homo sapiens
26 EBP  
Two-hybrid Homo sapiens
27 EVI2B 2124
Two-hybrid Homo sapiens
28 TMPRSS2 7113
Two-hybrid Homo sapiens
29 MOV10 4343
Affinity Capture-RNA Homo sapiens
30 HSD17B13  
Two-hybrid Homo sapiens
31 STX1A 6804
Two-hybrid Homo sapiens
32 HIBADH 11112
Two-hybrid Homo sapiens
33 SLC10A1  
Two-hybrid Homo sapiens
34 FAM174A 345757
Two-hybrid Homo sapiens
35 FAM134C 162427
Two-hybrid Homo sapiens
36 CREB3  
Two-hybrid Homo sapiens
37 KRAS 3845
Proximity Label-MS Homo sapiens
38 TMX2 51075
Two-hybrid Homo sapiens
39 CACNG1  
Affinity Capture-MS Homo sapiens
40 UPK1A 11045
Affinity Capture-MS Homo sapiens
41 PRSS23 11098
Two-hybrid Homo sapiens
42 RAB2A 5862
Proximity Label-MS Homo sapiens
43 ELOVL4  
Two-hybrid Homo sapiens
44 ZDHHC15 158866
Two-hybrid Homo sapiens
45 GNAI3 2773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM222 is involved
No pathways found





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