Gene description for PTGES
Gene name prostaglandin E synthase
Gene symbol PTGES
Other names/aliases MGST-IV
MGST1-L1
MGST1L1
MPGES
PGES
PIG12
PP102
PP1294
TP53I12
mPGES-1
Species Homo sapiens
 Database cross references - PTGES
ExoCarta ExoCarta_9536
Vesiclepedia VP_9536
Entrez Gene 9536
HGNC 9599
MIM 605172
UniProt O14684  
 PTGES identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTGES
Molecular Function
    glutathione transferase activity GO:0004364 IDA
    glutathione peroxidase activity GO:0004602 IDA
    prostaglandin-D synthase activity GO:0004667 IEA
    protein binding GO:0005515 IPI
    glutathione binding GO:0043295 IDA
    prostaglandin-E synthase activity GO:0050220 IBA
    prostaglandin-E synthase activity GO:0050220 IDA
Biological Process
    prostaglandin biosynthetic process GO:0001516 IBA
    prostaglandin biosynthetic process GO:0001516 IDA
    prostaglandin biosynthetic process GO:0001516 IEA
    prostaglandin metabolic process GO:0006693 TAS
    signal transduction GO:0007165 NAS
    cell population proliferation GO:0008283 IEA
    negative regulation of cell population proliferation GO:0008285 IEA
    sensory perception of pain GO:0019233 ISS
    regulation of fever generation GO:0031620 ISS
    positive regulation of prostaglandin secretion GO:0032308 IEA
    regulation of inflammatory response GO:0050727 ISS
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    nuclear envelope lumen GO:0005641 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified PTGES in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTGES
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GIMAP1  
Two-hybrid Homo sapiens
2 BET1 10282
Two-hybrid Homo sapiens
3 EHHADH 1962
Two-hybrid Homo sapiens
4 TMEM19  
Two-hybrid Homo sapiens
5 PLP2 5355
Two-hybrid Homo sapiens
6 PTGES 9536
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
7 GOLT1B 51026
Affinity Capture-MS Homo sapiens
8 VAMP4 8674
Two-hybrid Homo sapiens
9 SMCO4  
Two-hybrid Homo sapiens
10 USP9X 8239
Affinity Capture-Western Homo sapiens
11 YIF1A 10897
Two-hybrid Homo sapiens
12 VAPB 9217
Two-hybrid Homo sapiens
13 TMEM65 157378
Two-hybrid Homo sapiens
14 GIMAP5  
Two-hybrid Homo sapiens
15 TMEM222 84065
Two-hybrid Homo sapiens
16 SEC22A  
Two-hybrid Homo sapiens
17 SERP2  
Two-hybrid Homo sapiens
18 C4orf3  
Two-hybrid Homo sapiens
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