Gene description for FBXW8
Gene name F-box and WD repeat domain containing 8
Gene symbol FBXW8
Other names/aliases FBW6
FBW8
FBX29
FBXO29
FBXW6
Species Homo sapiens
 Database cross references - FBXW8
ExoCarta ExoCarta_26259
Entrez Gene 26259
HGNC 13597
MIM 609073
UniProt Q8N3Y1  
 FBXW8 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FBXW8
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-protein transferase activity GO:0004842 IDA
Biological Process
    protein ubiquitination GO:0016567 IEA
    spongiotrophoblast layer development GO:0060712 IEA
    positive regulation of dendrite morphogenesis GO:0050775 ISS
    Golgi organization GO:0007030 ISS
    cell proliferation GO:0008283 IDA
    labyrinthine layer blood vessel development GO:0060716 IEA
Subcellular Localization
    Cul7-RING ubiquitin ligase complex GO:0031467 IDA
    SCF ubiquitin ligase complex GO:0019005 IEA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    3M complex GO:1990393 IDA
 Experiment description of studies that identified FBXW8 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FBXW8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CUL7  
Affinity Capture-Western Homo sapiens
2 RBX1 9978
Affinity Capture-Western Homo sapiens
3 SKP1 6500
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which FBXW8 is involved
PathwayEvidenceSource
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here