Gene description for SPRED2
Gene name	sprouty-related, EVH1 domain containing 2
Gene symbol	SPRED2
Other names/aliases	Spred-2
Species	Homo sapiens
Database cross references - SPRED2
ExoCarta	ExoCarta_200734
Vesiclepedia	VP_200734
Entrez Gene	200734
HGNC	17722
MIM	609292
UniProt	Q7Z698
SPRED2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for SPRED2

Molecular Function     stem cell factor receptor binding GO:0005173 ISS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IBA     protein kinase binding GO:0019901 IPI     protein serine/threonine kinase inhibitor activity GO:0030291 ISS Biological Process     negative regulation of epithelial to mesenchymal transition GO:0010719 ISS     negative regulation of peptidyl-threonine phosphorylation GO:0010801 IMP     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISS     negative regulation of MAPK cascade GO:0043409 ISS     positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 ISS     negative regulation of ERK1 and ERK2 cascade GO:0070373 IBA     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     regulation of protein deacetylation GO:0090311 ISS     negative regulation of lens fiber cell differentiation GO:1902747 ISS Subcellular Localization     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     transport vesicle membrane GO:0030658 IEA