Gene description for TESK1
Gene name testis-specific kinase 1
Gene symbol TESK1
Other names/aliases -
Species Homo sapiens
 Database cross references - TESK1
ExoCarta ExoCarta_7016
Entrez Gene 7016
HGNC 11731
MIM 601782
UniProt Q15569  
 TESK1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for TESK1
Molecular Function
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    metal ion binding GO:0046872 IEA
    protein tyrosine kinase activity GO:0004713 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 IEA
    protein binding GO:0005515 IPI
Biological Process
    cell junction assembly GO:0034329 TAS
    spermatogenesis GO:0007283 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TESK1 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TESK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAB 7529
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 SPRY4 81848
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TESK1 is involved
PathwayEvidenceSource
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here