Gene description for SPRY1
Gene name	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
Gene symbol	SPRY1
Other names/aliases	hSPRY1
Species	Homo sapiens
Database cross references - SPRY1
ExoCarta	ExoCarta_10252
Vesiclepedia	VP_10252
Entrez Gene	10252
HGNC	11269
MIM	602465
UniProt	O43609
SPRY1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Urine	21557262

Gene ontology annotations for SPRY1

Molecular Function     protein binding GO:0005515 IPI Biological Process     establishment of mitotic spindle orientation GO:0000132 IEA     metanephros development GO:0001656 IEA     ureteric bud development GO:0001657 IEA     organ induction GO:0001759 IEA     negative regulation of cell population proliferation GO:0008285 IEA     negative regulation of epithelial to mesenchymal transition GO:0010719 ISS     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISS     negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 IBA     negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 IMP     negative regulation of Ras protein signal transduction GO:0046580 IBA     animal organ development GO:0048513 IBA     negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 IEA     bud elongation involved in lung branching GO:0060449 IEA     epithelial to mesenchymal transition involved in cardiac fibroblast development GO:0060940 ISS     ERK1 and ERK2 cascade GO:0070371 IEA     negative regulation of ERK1 and ERK2 cascade GO:0070373 IBA     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     negative regulation of lens fiber cell differentiation GO:1902747 ISS Subcellular Localization     nucleoplasm GO:0005654 IDA     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 ISS     cytosol GO:0005829 TAS     plasma membrane GO:0005886 TAS