Gene description for HRG
Gene name	histidine-rich glycoprotein
Gene symbol	HRG
Other names/aliases	HPRG HRGP THPH11
Species	Homo sapiens
Database cross references - HRG
ExoCarta	ExoCarta_3273
Entrez Gene	3273
HGNC	5181
MIM	142640
UniProt	P04196
HRG identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Urine	19056867

Gene ontology annotations for HRG

Molecular Function     immunoglobulin binding GO:0019865 IDA     protein binding GO:0005515 IPI     serine-type endopeptidase inhibitor activity GO:0004867 IEA     heme binding GO:0020037 IDA     cysteine-type endopeptidase inhibitor activity GO:0004869 IEA     metal ion binding GO:0046872 IDA     heparin binding GO:0008201 IDA     receptor binding GO:0005102 IDA     heparan sulfate proteoglycan binding GO:0043395 IDA     zinc ion binding GO:0008270 IDA Biological Process     defense response to fungus GO:0050832 IDA     negative regulation of cell adhesion GO:0007162 IDA     regulation of protein complex assembly GO:0043254 IDA     positive regulation of apoptotic process GO:0043065 IDA     platelet degranulation GO:0002576 TAS     fibrinolysis GO:0042730 TAS     negative regulation of angiogenesis GO:0016525 IDA     positive regulation of focal adhesion assembly GO:0051894 IDA     negative regulation of blood vessel endothelial cell migration GO:0043537 ISS     angiogenesis GO:0001525 IEA     regulation of transcription from RNA polymerase II promoter in response to iron GO:0034395 IEA     regulation of blood coagulation GO:0030193 IDA     positive regulation of immune response to tumor cell GO:0002839 IDA     blood coagulation GO:0007596 TAS     regulation of peptidyl-tyrosine phosphorylation GO:0050730 IDA     regulation of platelet activation GO:0010543 ISS     negative regulation of cell proliferation GO:0008285 IDA     regulation of actin cytoskeleton organization GO:0032956 IDA     regulation of gene expression GO:0010468 IDA     negative regulation of cell adhesion mediated by integrin GO:0033629 IDA     heme export GO:0097037 IEA     negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IDA     negative regulation of fibrinolysis GO:0051918 IEA     platelet activation GO:0030168 TAS     negative regulation of endothelial cell chemotaxis GO:2001027 IDA     negative regulation of lamellipodium assembly GO:0010593 IDA     negative regulation of cell growth GO:0030308 IDA     response to organic cyclic compound GO:0014070 IEA     positive regulation of blood vessel remodeling GO:2000504 IDA     chemotaxis GO:0006935 IEA     negative regulation of endopeptidase activity GO:0010951 IEA Subcellular Localization     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 TAS     phagolysosome membrane GO:0061474 IEA     extracellular region GO:0005576 TAS     blood microparticle GO:0072562 IDA     platelet alpha granule lumen GO:0031093 TAS     endolysosome GO:0036019 IEA