Gene description for LTBP4
Gene name latent transforming growth factor beta binding protein 4
Gene symbol LTBP4
Other names/aliases ARCL1C
LTBP-4
LTBP4L
LTBP4S
Species Homo sapiens
 Database cross references - LTBP4
ExoCarta ExoCarta_8425
Vesiclepedia VP_8425
Entrez Gene 8425
HGNC 6717
MIM 604710
UniProt Q8N2S1  
 LTBP4 identified in exosomes derived from the following tissue/cell type
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
 Gene ontology annotations for LTBP4
Molecular Function
    calcium ion binding GO:0005509 NAS
    glycosaminoglycan binding GO:0005539 NAS
    integrin binding GO:0005178 NAS
    transforming growth factor beta binding GO:0050431 IPI
    protein binding GO:0005515 IPI
    transforming growth factor beta-activated receptor activity GO:0005024 NAS
Biological Process
    regulation of cell differentiation GO:0045595 TAS
    regulation of proteolysis GO:0030162 IDA
    multicellular organismal development GO:0007275 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    extracellular matrix organization GO:0030198 TAS
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 TAS
    regulation of cell growth GO:0001558 TAS
    protein folding GO:0006457 TAS
    growth hormone secretion GO:0030252 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular matrix GO:0031012 IDA
    cell GO:0005623 TAS
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
    proteinaceous extracellular matrix GO:0005578 IDA
 Experiment description of studies that identified LTBP4 in exosomes
1
Experiment ID 219
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|CD9
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 220
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|CD9
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 221
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|CD9
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LTBP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFB1 7040
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which LTBP4 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres TAS Reactome





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