Gene description for LTBP4
Gene name latent transforming growth factor beta binding protein 4
Gene symbol LTBP4
Other names/aliases ARCL1C
LTBP-4
LTBP4L
LTBP4S
Species Homo sapiens
 Database cross references - LTBP4
ExoCarta ExoCarta_8425
Vesiclepedia VP_8425
Entrez Gene 8425
HGNC 6717
MIM 604710
UniProt Q8N2S1  
 LTBP4 identified in exosomes derived from the following tissue/cell type
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
 Gene ontology annotations for LTBP4
Molecular Function
    transforming growth factor beta receptor activity GO:0005024 NAS
    integrin binding GO:0005178 NAS
    extracellular matrix structural constituent GO:0005201 RCA
    calcium ion binding GO:0005509 NAS
    protein binding GO:0005515 IPI
    glycosaminoglycan binding GO:0005539 NAS
    transforming growth factor beta binding GO:0050431 IBA
    transforming growth factor beta binding GO:0050431 IDA
    transforming growth factor beta binding GO:0050431 IPI
Biological Process
    regulation of cell growth GO:0001558 TAS
    protein folding GO:0006457 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 TAS
    hormone secretion GO:0046879 IEA
    elastic fiber assembly GO:0048251 ISS
Subcellular Localization
    microfibril GO:0001527 ISS
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular matrix GO:0031012 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IDA
 Experiment description of studies that identified LTBP4 in exosomes
1
Experiment ID 219
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 220
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 221
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LTBP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF574  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 E4F1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZNF669  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ZNF707  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MFAP5  
Affinity Capture-MS Homo sapiens
6 CACNA1A  
Two-hybrid Homo sapiens
7 OIT3 170392
Affinity Capture-MS Homo sapiens
8 C9orf163  
Affinity Capture-MS Homo sapiens
9 CUL3 8452
Affinity Capture-MS Homo sapiens
10 GFI1B  
Two-hybrid Homo sapiens
11 DYNLT1 6993
Proximity Label-MS Homo sapiens
12 NOTCH2 4853
Affinity Capture-MS Homo sapiens
13 LDLRAD1  
Affinity Capture-MS Homo sapiens
14 ZNF324B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 VWCE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LTBP2 4053
Affinity Capture-MS Homo sapiens
17 ATXN7  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
18 ZNF169 169841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CFC1  
Affinity Capture-MS Homo sapiens
20 TRIM66  
Affinity Capture-MS Homo sapiens
21 PRG2  
Affinity Capture-MS Homo sapiens
22 HRG 3273
Affinity Capture-MS Homo sapiens
23 RPL10 6134
Affinity Capture-MS Homo sapiens
24 CRY1  
Two-hybrid Homo sapiens
25 C4orf26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 FBLN1 2192
Two-hybrid Homo sapiens
27 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ATN1  
Two-hybrid Homo sapiens
29 NELL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 APEX1 328
Affinity Capture-RNA Homo sapiens
31 CUL9  
Affinity Capture-MS Homo sapiens
32 ITSN2 50618
Two-hybrid Homo sapiens
33 NELL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ZNF764 92595
Affinity Capture-MS Homo sapiens
35 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NLRP3  
Affinity Capture-MS Homo sapiens
38 NTN5  
Affinity Capture-MS Homo sapiens
39 FBXO2 26232
Affinity Capture-MS Homo sapiens
40 ZNF74  
Affinity Capture-MS Homo sapiens
41 CRKL 1399
Two-hybrid Homo sapiens
42 ZNF517  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ZNF8  
Affinity Capture-MS Homo sapiens
44 FRAT1 10023
Two-hybrid Homo sapiens
45 TRIB3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 DNAJC10 54431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 MZF1  
Affinity Capture-MS Homo sapiens
48 ZNF550  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ZNF563  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 FBLN5 10516
Affinity Capture-MS Homo sapiens
51 SLC39A7 7922
Affinity Capture-MS Homo sapiens
52 RAC1 5879
Two-hybrid Homo sapiens
53 ZNF331  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 BRD3 8019
Affinity Capture-MS Homo sapiens
55 FOXD4L6  
Affinity Capture-MS Homo sapiens
56 NIN 51199
Proximity Label-MS Homo sapiens
57 ZNF263  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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