Gene description for FRAT1
Gene name frequently rearranged in advanced T-cell lymphomas 1
Gene symbol FRAT1
Other names/aliases -
Species Homo sapiens
 Database cross references - FRAT1
ExoCarta ExoCarta_10023
Entrez Gene 10023
HGNC 3944
MIM 602503
UniProt Q92837  
 FRAT1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 25330373    
 Gene ontology annotations for FRAT1
Biological Process
    Wnt signaling pathway GO:0016055 IEA
    embryonic axis specification GO:0000578 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FRAT1 in exosomes
1
Experiment ID 223
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25330373    
Organism Homo sapiens
Experiment description Deep sequencing of RNA from three different extracellular vesicle (EV) subtypes released from the human LIM1863 colon cancer cell line uncovers distinct miRNA-enrichment signatures
Authors Ji H, Chen M, Greening DW, He W, Rai A, Zhang W, Simpson RJ
Journal name PLoS One
Publication year 2014
Sample Colorectal cancer cells
Sample name LIM1863
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Immunobeads (EpCAM)
Immunobeads (A33)
Flotation density -
Molecules identified in the study miRNA
Protein
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for FRAT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DVL1 1855
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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