Gene description for PIAS1
Gene name	protein inhibitor of activated STAT, 1
Gene symbol	PIAS1
Other names/aliases	DDXBP1 GBP GU/RH-II ZMIZ3
Species	Homo sapiens
Database cross references - PIAS1
ExoCarta	ExoCarta_8554
Vesiclepedia	VP_8554
Entrez Gene	8554
HGNC	2752
MIM	603566
UniProt	O75925
PIAS1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for PIAS1

Molecular Function     SUMO ligase activity GO:0061665 IDA     transcription coactivator activity GO:0003713 NAS     protein binding GO:0005515 IPI     DNA binding GO:0003677 IEA     enzyme binding GO:0019899 IPI     ubiquitin protein ligase binding GO:0031625 IEA     zinc ion binding GO:0008270 IEA     androgen receptor binding GO:0050681 NAS     protein domain specific binding GO:0019904 IEA     ligase activity GO:0016874 IEA     transcription corepressor activity GO:0003714 TAS Biological Process     positive regulation of smooth muscle cell differentiation GO:0051152 IEA     positive regulation of transcription, DNA-templated GO:0045893 NAS     interferon-gamma-mediated signaling pathway GO:0060333 TAS     JAK-STAT cascade GO:0007259 TAS     protein-DNA complex assembly GO:0065004 IEA     protein sumoylation GO:0016925 TAS     regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS     cytokine-mediated signaling pathway GO:0019221 TAS     positive regulation of protein sumoylation GO:0033235 IDA     androgen receptor signaling pathway GO:0030521 NAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     regulation of cell proliferation GO:0042127 ISS     post-translational protein modification GO:0043687 TAS     cellular protein metabolic process GO:0044267 TAS     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS     transcription, DNA-templated GO:0006351 IEA     spermatogenesis GO:0007283 IEA Subcellular Localization     nuclear speck GO:0016607 IEA     PML body GO:0016605 ISS     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS