Gene description for Dnm1
Gene name dynamin 1
Gene symbol Dnm1
Other names/aliases Dnm
Species Rattus norvegicus
 Database cross references - Dnm1
ExoCarta ExoCarta_140694
Entrez Gene 140694
UniProt P21575  
 Dnm1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Dnm1
Molecular Function
    D2 dopamine receptor binding GO:0031749 IPI
    nitric-oxide synthase binding GO:0050998 IPI
    protein C-terminus binding GO:0008022 IPI
    GTPase activity GO:0003924 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 TAS
    protein kinase binding GO:0019901 ISO
    poly(A) RNA binding GO:0044822 ISO
    protein complex binding GO:0032403 IPI
    protein dimerization activity GO:0046983 ISO
    GTP binding GO:0005525 IEA
Biological Process
    endosome organization GO:0007032 ISO
    receptor-mediated endocytosis GO:0006898 ISO
    endocytosis GO:0006897 ISO
    protein tetramerization GO:0051262 ISO
    clathrin-mediated endocytosis GO:0072583 IEA
    positive regulation of synaptic vesicle recycling GO:1903423 IMP
    receptor internalization GO:0031623 IMP
    adult locomotory behavior GO:0008344 ISO
    sensory perception of sound GO:0007605 ISO
    G-protein coupled receptor internalization GO:0002031 IMP
    toxin transport GO:1901998 ISO
    metabolic process GO:0008152 IEA
    synaptic transmission, GABAergic GO:0051932 ISO
Subcellular Localization
    myelin sheath GO:0043209 ISO
    photoreceptor inner segment GO:0001917 ISO
    synaptic vesicle GO:0008021 IDA
    synapse GO:0045202 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 TAS
    microtubule GO:0005874 IEA
    varicosity GO:0043196 IDA
    membrane coat GO:0030117 ISO
    protein complex GO:0043234 IDA
    Golgi apparatus GO:0005794 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Dnm1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Dnm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Amph1  
Reconstituted Complex Rattus norvegicus
2 Clic4 83718
Affinity Capture-MS Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Reconstituted Complex Rattus norvegicus
3 CLIC4 25932
Co-fractionation Homo sapiens
View the network image/svg+xml



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