Gene description for Nme2
Gene name NME/NM23 nucleoside diphosphate kinase 2
Gene symbol Nme2
Other names/aliases NDKB
Species Rattus norvegicus
 Database cross references - Nme2
ExoCarta ExoCarta_83782
Entrez Gene 83782
UniProt P19804  
 Nme2 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
 Gene ontology annotations for Nme2
Molecular Function
    drug binding GO:0008144 IPI
    intermediate filament binding GO:0019215 IPI
    ATP binding GO:0005524 IEA
    protein histidine kinase activity GO:0004673 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
    nucleoside diphosphate kinase activity GO:0004550 ISO
    enzyme binding GO:0019899 IPI
    fatty acid binding GO:0005504 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    positive regulation of keratinocyte differentiation GO:0045618 ISS
    nucleoside diphosphate phosphorylation GO:0006165 IDA
    response to growth hormone GO:0060416 IEP
    positive regulation of neuron projection development GO:0010976 IMP
    protein autophosphorylation GO:0046777 IDA
    nucleoside triphosphate biosynthetic process GO:0009142 ISO
    positive regulation of epithelial cell proliferation GO:0050679 ISS
    peptidyl-histidine phosphorylation GO:0018106 IEA
    regulation of apoptotic process GO:0042981 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    positive regulation of cAMP biosynthetic process GO:0030819 IMP
    protein oligomerization GO:0051259 IDA
    integrin-mediated signaling pathway GO:0007229 ISS
    negative regulation of myeloid leukocyte differentiation GO:0002762 IDA
    CTP biosynthetic process GO:0006241 IDA
    cellular response to fatty acid GO:0071398 IEP
    UTP biosynthetic process GO:0006228 IDA
    cellular response to oxidative stress GO:0034599 IEP
    negative regulation of apoptotic process GO:0043066 ISS
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 ISO
    cellular response to glucose stimulus GO:0071333 IEP
    regulation of epidermis development GO:0045682 ISS
    GTP biosynthetic process GO:0006183 IDA
Subcellular Localization
    cell periphery GO:0071944 ISS
    plasma membrane GO:0005886 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    cytosol GO:0005829 IBA
    myelin sheath GO:0043209 ISO
    lamellipodium GO:0030027 ISS
    focal adhesion GO:0005925 ISS
    mitochondrion GO:0005739 ISO
    mitochondrial membrane GO:0031966 IDA
    intermediate filament GO:0005882 IDA
    nucleus GO:0005634 ISO
    intracellular GO:0005622 IBA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 ISO
    ruffle GO:0001726 ISS
 Experiment description of studies that identified Nme2 in exosomes
Experiment ID 225
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
Experiment ID 97
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Nme2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nme2 is involved
No pathways found

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