Gene description for LSM3
Gene name LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Gene symbol LSM3
Other names/aliases SMX4
USS2
YLR438C
Species Homo sapiens
 Database cross references - LSM3
ExoCarta ExoCarta_27258
Entrez Gene 27258
HGNC 17874
MIM 607283
UniProt P62310  
 LSM3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for LSM3
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IC
    gene expression GO:0010467 TAS
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
    mRNA processing GO:0006397 TAS
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
Subcellular Localization
    nucleus GO:0005634 TAS
    cytosol GO:0005829 TAS
    catalytic step 2 spliceosome GO:0071013 IDA
 Experiment description of studies that identified LSM3 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for LSM3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTP14A 10813
Two-hybrid Homo sapiens
2 LSM5 23658
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
3 LSM6 11157
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
4 XPC  
Two-hybrid Homo sapiens
5 LSM8  
Invitro Homo sapiens
6 GDF9 2661
Two-hybrid Homo sapiens
7 LSM2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
8 LSM7  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 LSM10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
10 SNRPD3 6634
Two-hybrid Homo sapiens
11 SMN1 6606
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
12 SNRPE 6635
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
13 XRN2 22803
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
14 EEF1A1 1915
Two-hybrid Homo sapiens
15 LSM1  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
16 CCDC45  
Affinity Capture-MS Homo sapiens
17 LSM4  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which LSM3 is involved
PathwayEvidenceSource
mRNA decay by 5' to 3' exoribonuclease TAS Reactome





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