Gene description for TRAPPC2
Gene name trafficking protein particle complex 2
Gene symbol TRAPPC2
Other names/aliases MIP2A
SEDL
SEDT
TRAPPC2P1
TRS20
ZNF547L
hYP38334
Species Homo sapiens
 Database cross references - TRAPPC2
ExoCarta ExoCarta_6399
Vesiclepedia VP_6399
Entrez Gene 6399
HGNC 23068
MIM 300202
UniProt P0DI82   P0DI81  
 TRAPPC2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TRAPPC2
Molecular Function
    protein binding GO:0005515 IPI
    transmembrane transporter binding GO:0044325 IPI
Biological Process
    skeletal system development GO:0001501 IMP
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 NAS
    vesicle coating GO:0006901 NAS
    COPII vesicle coating GO:0048208 NAS
    vesicle tethering GO:0099022 NAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 NAS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    cytosol GO:0005829 TAS
    TRAPP complex GO:0030008 IBA
    TRAPP complex GO:0030008 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    TRAPPII protein complex GO:1990071 NAS
    TRAPPIII protein complex GO:1990072 NAS
 Experiment description of studies that identified TRAPPC2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRAPPC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAPPC2 6399
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 ACTR2 10097
Affinity Capture-MS Homo sapiens
3 CSTL1  
Affinity Capture-MS Homo sapiens
4 TRAPPC9 83696
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 KLC2 64837
Affinity Capture-MS Homo sapiens
6 ZNF438  
Two-hybrid Homo sapiens
7 CABS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PITX1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 CMTM8  
Affinity Capture-MS Homo sapiens
10 STMN4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 YWHAE 7531
Affinity Capture-MS Homo sapiens
12 GLB1 2720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ISCA1  
Affinity Capture-MS Homo sapiens
14 SLC18A2  
Affinity Capture-MS Homo sapiens
15 MARK2 2011
Affinity Capture-MS Homo sapiens
16 ACTR3 10096
Affinity Capture-MS Homo sapiens
17 BCL2L14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 YWHAG 7532
Affinity Capture-MS Homo sapiens
19 EPS15L1 58513
Two-hybrid Homo sapiens
20 YWHAH 7533
Affinity Capture-MS Homo sapiens
21 CGA  
Affinity Capture-MS Homo sapiens
22 TRAPPC11 60684
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 UQCC2  
Two-hybrid Homo sapiens
24 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 APPL1 26060
Affinity Capture-MS Homo sapiens
26 YWHAB 7529
Affinity Capture-MS Homo sapiens
27 DNASE2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TBC1D14 57533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ARPC2 10109
Affinity Capture-MS Homo sapiens
30 TRAPPC6A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ARL1 400
Affinity Capture-MS Homo sapiens
32 RAB43 339122
Affinity Capture-MS Homo sapiens
33 ZBED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
34 TRAPPC2L 51693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 JOSD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
36 ZNF655  
Two-hybrid Homo sapiens
37 PRMT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ENO1 2023
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
39 NICN1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 SLC25A35  
Two-hybrid Homo sapiens
41 RAP2A 5911
Affinity Capture-MS Homo sapiens
42 TRAPPC3L  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 RUFY4  
Affinity Capture-MS Homo sapiens
44 SNAPC5  
Two-hybrid Homo sapiens
45 PCDH20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CAMSAP3  
Affinity Capture-MS Homo sapiens
48 CRYAB 1410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 MBL2 4153
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 YWHAZ 7534
Affinity Capture-MS Homo sapiens
51 TUBB4B 10383
Affinity Capture-MS Homo sapiens
52 OPRL1 4987
Affinity Capture-MS Homo sapiens
53 SART1 9092
Affinity Capture-MS Homo sapiens
54 KIAA0430  
Affinity Capture-MS Homo sapiens
55 TRAPPC1 58485
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 Trappc8  
Affinity Capture-MS Mus musculus
57 LSM3 27258
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
58 TRAPPC4 51399
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 YWHAQ 10971
Affinity Capture-MS Homo sapiens
60 TRAPPC12 51112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 RAF1 5894
Affinity Capture-MS Homo sapiens
62 KANK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 NR5A1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
64 ENTHD2  
Two-hybrid Homo sapiens
65 BAIAP2 10458
Affinity Capture-MS Homo sapiens
66 ARPC1A 10552
Affinity Capture-MS Homo sapiens
67 TRAPPC6B 122553
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 MARK3 4140
Affinity Capture-MS Homo sapiens
69 C7orf43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CLIC1 1192
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
71 TRAPPC5 126003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
72 PAPOLA 10914
Affinity Capture-MS Homo sapiens
73 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 NME4 4833
Two-hybrid Homo sapiens
75 TRAPPC8 22878
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 INCA1  
Two-hybrid Homo sapiens
77 TRMT61B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
79 TRAPPC13 80006
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 GAB2 9846
Affinity Capture-MS Homo sapiens
81 UBB 7314
Affinity Capture-MS Homo sapiens
82 CLASP1 23332
Affinity Capture-MS Homo sapiens
83 RAB7A 7879
Proximity Label-MS Homo sapiens
84 TRAPPC3 27095
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 KCTD1 284252
Two-hybrid Homo sapiens
86 MBD3L1  
Two-hybrid Homo sapiens
87 MTL5  
Affinity Capture-MS Homo sapiens
88 BDH2 56898
Affinity Capture-MS Homo sapiens
89 CLIC2 1193
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRAPPC2 is involved
No pathways found





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