Gene description for CLIC2
Gene name chloride intracellular channel 2
Gene symbol CLIC2
Other names/aliases CLIC2b
MRXS32
XAP121
Species Homo sapiens
 Database cross references - CLIC2
ExoCarta ExoCarta_1193
Entrez Gene 1193
HGNC 2063
MIM 300138
UniProt O15247  
 CLIC2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CLIC2
Molecular Function
    glutathione peroxidase activity GO:0004602 IDA
    chloride channel activity GO:0005254 IEA
    protein binding GO:0005515 IPI
    voltage-gated ion channel activity GO:0005244 IEA
    glutathione transferase activity GO:0004364 IDA
Biological Process
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 IDA
    positive regulation of binding GO:0051099 IDA
    negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 IDA
    signal transduction GO:0007165 TAS
    transport GO:0006810 TAS
    chloride transmembrane transport GO:1902476 IEA
    oxidation-reduction process GO:0055114 IDA
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 IC
Subcellular Localization
    intracellular GO:0005622 IDA
    nucleus GO:0005634 TAS
    cytoplasm GO:0005737 TAS
    chloride channel complex GO:0034707 IEA
 Experiment description of studies that identified CLIC2 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLIC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAPPC2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CLIC2 is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here