Gene description for CLIC5
Gene name chloride intracellular channel 5
Gene symbol CLIC5
Other names/aliases DFNB102
DFNB103
MST130
MSTP130
Species Homo sapiens
 Database cross references - CLIC5
ExoCarta ExoCarta_53405
Entrez Gene 53405
HGNC 13517
MIM 607293
UniProt Q9NZA1  
 CLIC5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for CLIC5
Molecular Function
    protein binding GO:0005515 IPI
    chloride channel activity GO:0005254 IEA
    voltage-gated ion channel activity GO:0005244 IEA
Biological Process
    transport GO:0006810 NAS
    neuromuscular process controlling balance GO:0050885 IEA
    female pregnancy GO:0007565 TAS
    protein localization GO:0008104 IEA
    sensory perception of sound GO:0007605 IMP
    chloride transport GO:0006821 IDA
    auditory receptor cell stereocilium organization GO:0060088 IEA
    diet induced thermogenesis GO:0002024 IEA
    regulation of ion transmembrane transport GO:0034765 IEA
    chloride transmembrane transport GO:1902476 IEA
Subcellular Localization
    cell cortex GO:0005938 IEA
    extracellular exosome GO:0070062 IDA
    Golgi apparatus GO:0005794 IEA
    actin cytoskeleton GO:0015629 IDA
    stereocilium GO:0032420 IEA
    chloride channel complex GO:0034707 IEA
    microtubule organizing center GO:0005815 IEA
 Experiment description of studies that identified CLIC5 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CLIC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSN 2934
Invitro Homo sapiens
2 IQGAP1 8826
Invitro Homo sapiens
3 EZR 7430
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CLIC5 is involved
No pathways found





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