Gene description for CLIC6
Gene name chloride intracellular channel 6
Gene symbol CLIC6
Other names/aliases CLIC1L
Species Homo sapiens
 Database cross references - CLIC6
ExoCarta ExoCarta_54102
Vesiclepedia VP_54102
Entrez Gene 54102
HGNC 2065
MIM 615321
UniProt Q96NY7  
 CLIC6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Urine 19056867    
 Gene ontology annotations for CLIC6
Molecular Function
    chloride channel activity GO:0005254 IDA
    oxidoreductase activity GO:0016491 IEA
    D2 dopamine receptor binding GO:0031749 IBA
    D3 dopamine receptor binding GO:0031750 IBA
    D4 dopamine receptor binding GO:0031751 IBA
Biological Process
    chloride transmembrane transport GO:1902476 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IEA
    chloride channel complex GO:0034707 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CLIC6 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CLIC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DRD4  
Two-hybrid Homo sapiens
2 CLIC4 25932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CLIC5 53405
Affinity Capture-MS Homo sapiens
4 DRD2  
Two-hybrid Homo sapiens
5 DRD3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CLIC6 is involved
No pathways found





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