Gene description for EPS15L1
Gene name epidermal growth factor receptor pathway substrate 15-like 1
Gene symbol EPS15L1
Other names/aliases EPS15R
Species Homo sapiens
 Database cross references - EPS15L1
ExoCarta ExoCarta_58513
Entrez Gene 58513
HGNC 24634
UniProt Q9UBC2  
 EPS15L1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for EPS15L1
Molecular Function
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IEA
Biological Process
    endocytosis GO:0006897 IEA
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 TAS
    nucleus GO:0005634 IEA
    clathrin coat of coated pit GO:0030132 IEA
 Experiment description of studies that identified EPS15L1 in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EPS15L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HRBL  
Invitro Homo sapiens
2 HRB  
Two-hybrid Homo sapiens
Phenotypic Enhancement Homo sapiens
3 EPN1  
Invitro Homo sapiens
4 STON2 85439
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which EPS15L1 is involved
PathwayEvidenceSource
EGFR downregulation TAS Reactome





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