Gene description for UBQLN1
Gene name ubiquilin 1
Gene symbol UBQLN1
Other names/aliases DA41
DSK2
PLIC-1
UBQN
XDRP1
Species Homo sapiens
 Database cross references - UBQLN1
ExoCarta ExoCarta_29979
Entrez Gene 29979
HGNC 12508
MIM 605046
UniProt Q9UMX0  
 UBQLN1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for UBQLN1
Molecular Function
    protein domain specific binding GO:0019904 IEA
    polyubiquitin binding GO:0031593 IDA
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IPI
Biological Process
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 IMP
    negative regulation of autophagosome fusion GO:1902453 IMP
    negative regulation of store-operated calcium channel activity GO:1901340 IMP
    response to endoplasmic reticulum stress GO:0034976 IMP
    cellular response to hypoxia GO:0071456 IMP
    positive regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1903071 IMP
    regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902175 IMP
    regulation of protein ubiquitination GO:0031396 IDA
    regulation of autophagosome assembly GO:2000785 IMP
    regulation of macroautophagy GO:0016241 IMP
    positive regulation of protein ubiquitination GO:0031398 IDA
    aggrephagy GO:0035973 IDA
Subcellular Localization
    aggresome GO:0016235 IDA
    protein complex GO:0043234 IDA
    endoplasmic reticulum GO:0005783 IDA
    nucleoplasm GO:0005654 IDA
    perinuclear region of cytoplasm GO:0048471 NAS
    cytoplasm GO:0005737 IMP
    plasma membrane GO:0005886 IDA
    autophagosome GO:0005776 IDA
    proteasome complex GO:0000502 IEA
 Experiment description of studies that identified UBQLN1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBQLN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FZD7 8324
Two-hybrid Homo sapiens
2 KLHDC5  
Two-hybrid Homo sapiens
3 CD99 4267
Two-hybrid Homo sapiens
4 NBL1 4681
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
5 DKFZP564B147  
Two-hybrid Homo sapiens
6 CSTF2T  
Two-hybrid Homo sapiens
7 SMCR7  
Two-hybrid Homo sapiens
8 HSPA13 6782
Two-hybrid Homo sapiens
9 GABRD  
Two-hybrid Homo sapiens
10 PRO1580  
Two-hybrid Homo sapiens
11 RIC8A 60626
Two-hybrid Homo sapiens
12 PRPF40A 55660
Affinity Capture-MS Homo sapiens
13 PSEN2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 SMAD9  
Affinity Capture-MS Homo sapiens
15 HK2  
Two-hybrid Homo sapiens
16 MTOR 2475
Two-hybrid Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
17 PLA2G16 11145
Two-hybrid Homo sapiens
18 TRIM32 22954
Two-hybrid Homo sapiens
19 P4HB 5034
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
20 HGS 9146
Two-hybrid Homo sapiens
21 TFF1 7031
Two-hybrid Homo sapiens
22 SERPINI2  
Two-hybrid Homo sapiens
23 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 IGLC1 3537
Two-hybrid Homo sapiens
25 CSTF2  
Two-hybrid Homo sapiens
26 PSEN1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
27 EFEMP2 30008
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UBQLN1 is involved
No pathways found





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