Gene description for SOD3
Gene name superoxide dismutase 3, extracellular
Gene symbol SOD3
Other names/aliases EC-SOD
Species Homo sapiens
 Database cross references - SOD3
ExoCarta ExoCarta_6649
Entrez Gene 6649
HGNC 11181
MIM 185490
UniProt P08294  
 SOD3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 22723089    
 Gene ontology annotations for SOD3
Molecular Function
    heparin binding GO:0008201 IEA
    zinc ion binding GO:0008270 IBA
    copper ion binding GO:0005507 IBA
    protein binding GO:0005515 IPI
    superoxide dismutase activity GO:0004784 TAS
Biological Process
    response to reactive oxygen species GO:0000302 TAS
    response to copper ion GO:0046688 IEA
    response to hypoxia GO:0001666 IEA
    removal of superoxide radicals GO:0019430 IBA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IEA
    Golgi lumen GO:0005796 TAS
    trans-Golgi network GO:0005802 IEA
    cytoplasm GO:0005737 IBA
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified SOD3 in exosomes
1
Experiment ID 137
ISEV standards
EM
EV Biophysical techniques
HSP70|HSP90|RAB6
EV Cytosolic markers
CD10
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name PC3 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for SOD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SOD3 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species TAS Reactome





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