Gene description for ECSIT
Gene name ECSIT signalling integrator
Gene symbol ECSIT
Other names/aliases SITPEC
Species Homo sapiens
 Database cross references - ECSIT
ExoCarta ExoCarta_51295
Entrez Gene 51295
HGNC 29548
MIM 608388
UniProt Q9BQ95  
 ECSIT identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ECSIT
Molecular Function
    signal transducer activity GO:0004871 IEA
    oxidoreductase activity, acting on NAD(P)H GO:0016651 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
Biological Process
    oxidation-reduction process GO:0055114 IDA
    BMP signaling pathway GO:0030509 IEA
    mesoderm formation GO:0001707 IEA
    regulation of oxidoreductase activity GO:0051341 IDA
    innate immune response GO:0045087 IEA
Subcellular Localization
    transcription factor complex GO:0005667 IEA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified ECSIT in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ECSIT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IMMT 10989
Two-hybrid Homo sapiens
2 STRN4 29888
Two-hybrid Homo sapiens
3 SETDB1  
Two-hybrid Homo sapiens
4 TRAF6 7189
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 MAP3K1 4214
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ECSIT is involved
No pathways found

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